Results 131 to 140 of about 62,250 (302)

DNA mismatch repair, microsatellite instability and cancer

, 2002
989-994Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring ...
Vaish., Minal, Mittal, B
core  

Microsatellite instability in a population of sporadic colorectal cancers: correlation between genetic and pathological profiles [PDF]

, 2002
BACKGROUND: Tumours with high-frequency microsatellite instability exhibit unique genotype and phenotype features, whereas the difference between low-frequency microsatellite instability and apparently stable tumours is far from being clear.
De Filippo C., Caderni G., Biggeri A., Cianchi F., Dolara P., Tonelli F., Mini E., Luceri C., Guglielmi F., Messerini L.   +9 more
core  

Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer.

, 2004
Microsatellite instability and loss of heterozygosity has been implicated in ovarian carcinogenesis. The reported frequency of microsatellite instability in human ovarian cancer varies significantly owing to the use of heterogeneous tumor histotypes and ...
Gershenson, DM, Chang, KH, Liu, J, Luthra, R, Zheng, W, Broaddus, R, Thompson-Lanza, JA, Albarracin, CT   +7 more
core   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

The role of TMEM119 in gastric adenocarcinoma and its specific effects on immunity

Journal of International Medical Research
Objective To investigate the prognostic significance and immunological implication of transmembrane protein 119 (TMEM119) in stomach adenocarcinoma (STAD).
Yating Liu, Xin Yan, Caihao Qu, Futian Tang, Qian Wang, Yumin Li   +5 more
doaj   +1 more source

What Is the Evidence Base Regarding Early Onset Colorectal Cancer in Australia and New Zealand? A Scoping Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Early onset colorectal cancer (EoCRC), commonly defined as colorectal cancer diagnosed in people under 50 years of age, is increasing in incidence in Australia and New Zealand. The underlying cause of this remains unclear, despite its growing public health importance.
Tiffany J. Cherry, Dilshan Udayasiri, Ian P. Hayes   +2 more
wiley   +1 more source

Two Decades of Multimodal Management of Colorectal Liver Metastases With Long‐Term Outcomes

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long‐term survival following liver resection are contested.
Ali Mohtashami, Prajwol Shrestha, Sharon Chen, Jean‐Luc Vrisakis, Nazim Bhimani, Nick Pavlakis, Stephen J. Clarke, Connie I. Diakos, Matthew Wong, Thomas J. Hugh   +9 more
wiley   +1 more source

Microsatellite instability in endometrial cancer. Relation to histological subtypes

, 1999
Microsatellite instability in endometrial cancer: relation to histological ...
TRUBIA M, Taborelli M., COSSU A, FURLAN D, CAPELLA, CARLO RENATO, TABORELLI M, FURLAN, DANIELA, FRANCHI, Massimo Piergiuseppe, Tibiletti M. G., Cossu A., FRANCHI M, Furlan D., Taramelli R., Franchi M., Facco C., TIBILETTI MG, TIBILETTI M. G, FACCO C, RIVA, CRISTINA, Trubia M., TARAMELLI R, Riva C., RIVA C, CAPELLA C.   +23 more
core   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source