Results 151 to 160 of about 52,582 (257)

The Role of Microsatellite Instability in Endometrial Hyperplasia and Risk of Carcinoma Development. [PDF]

Biomedicines
Mollova-Kyosebekirova A, Uchikova E, Mihaylova A, Koleva-Ivanova M, Parahuleva M, Parahuleva N.   +5 more
europepmc   +1 more source

Genomic, Trop‐2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear.
Tomomi Sakamaki, Tatsuyuki Chiyoda, Kohei Nakamura, Reika Takamatsu, Ryutaro Kawano, Daisuke Ochiai, Mitsuyo Jisaka, Mio Takahashi, Takuma Yoshimura, Yumiko Kimura, Shinya Oki, Kensuke Sakai, Tomoko Yoshihama, Hiroshi Nishihara, Wataru Yamagami   +14 more
wiley   +1 more source

Comparison of immunohistochemistry, PCR, and NGS for the evaluation of mismatch repair deficiency and microsatellite instability in colorectal cancer: a retrospective study. [PDF]

Diagn Pathol
Wang L, Hu Y, Yuan H, Yu N, Xiao L, Jin J.   +5 more
europepmc   +1 more source

Exposure–Response Relationship of Dostarlimab in Primary Advanced/Recurrent Endometrial Cancer: Results From Interim Analysis 2 of Part 1 of the RUBY Trial

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
Abstract Dostarlimab in combination with carboplatin–paclitaxel was approved for primary advanced or recurrent endometrial cancer (pA/rEC). The first interim analysis (IA1) of RUBY Part 1 (NCT03981796) showed no significant exposure–response (ER) relationship for progression‐free survival or for the five most common dostarlimab‐related adverse events ...
Mita Kuchimanchi, Trine Lembrecht Jørgensen, Eva Hanze, Angela Jain, Oskar Alskär, Oleksandr Zub, Mark S. Shahin, Anthoula Koliadi, Bhavana Pothuri, Thomas Krivak, Mikalai Pishchyk, Yakir Segev, Floor J. Backes, Christine Gennigens, Sara Bouberhan, Stefan Zajic, Murad Melhem, Joseph Buscema   +17 more
wiley   +1 more source

Checkpoint inhibitors in microsatellite instability-high metastatic colorectal cancer: treatment strategies, specificities, and care management questions. [PDF]

ESMO Gastrointest Oncol
André T, Lonardi S, Zaanan A, Cohen R, Taieb J.   +4 more
europepmc   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non-Smokers and Non-Drinkers. [PDF]

J Oral Pathol Med
Mulder FJ, Gielgens TFB, de Ruiter EJ, de Bree R, van den Hout MFCM, Kremer B, Willems SM, Speel EJM.   +7 more
europepmc   +1 more source

Systemic immune‐inflammation indices and MSI‐H/dMMR status in colorectal cancer: Published evidence synthesis with exploratory local clinical and pathological corroboration

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSI‐H/dMMR colorectal cancer exhibits a distinct immune‐inflammatory profile characterised by lymphocyte enrichment, reduced tissue MPO/CD8 balance and context‐dependent systemic signals. Evidence synthesis suggests elevated NLR, while local data indicate attenuated inflammatory indices, highlighting discordance between systemic and tissue‐level immune
Yue Huang, Xuefei Chen, Zizhen Xu
wiley   +1 more source

Analysis of DNA mismatch repair and microsatellite instability in molecular typing of endometrial carcinoma. [PDF]

Discov Oncol
Li NM, Cheng HP, Zhou P, Li XH.
europepmc   +1 more source

A molecular landscape and prognosis signature based on histone tyrosine sulfation in pan‐cancer analysis

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
A pan‐cancer transcriptional signature based on histone tyrosine sulfation (HYsulf) reveals associations with immune infiltration, metabolic reprogramming and patient prognosis, thereby enabling the development of predictive nomograms for PCPG and UVM.
Meijuan Cai, Yuhao Liao, Jun Lin, Xumeng Chen, Jiale Wang, Zhijuan Li, Zhengjun Yang, DianKui Cai   +7 more
wiley   +1 more source