Results 161 to 170 of about 52,582 (257)

Improving the performance of polymerase chain reaction for microsatellite instability testing in endometrial cancer. [PDF]

Sci Rep
Mendiola M, Heredia-Soto V, Baillo A, Ruz-Caracuel I, Mena R, Berjón A, Escudero FJ, Pedregosa J, Hernandez A, Feliu J, Hardisson D, Redondo A.   +11 more
europepmc   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

Correction: A two-stage deep learning prediction system for colon cancer microsatellite instability status using CT images. [PDF]

Front Oncol
Cui S, Xiong X, Yang X, He J, Shen T.
europepmc   +1 more source

The Complete Mitochondrial Genome and Phylogenetic Position of the Pacific Spiny Dogfish Squalus suckleyi (Squaliformes: Squalidae)

Ecology and Evolution, Volume 16, Issue 8, August 2026.
The Pacific spiny dogfish (Squalus suckleyi) is a North Pacific shark of conservation consern that until now lacked a complete mitochondrial genome. We report its first mitogenome (16,738 bp; 37 genes), assembled from PacBio HiFi reads and recover it as sister to S.
Laure Inçaby, Sabrina Haney, Michael Phelps, Catherine S. Jones, Marcela Uliano‐Silva, Galice Hoarau, Leslie R. Noble   +6 more
wiley   +1 more source

Mucinous histology and resistance to immune checkpoint blockade in patients with microsatellite instability-high metastatic colorectal cancer. [PDF]

Oncologist
Nasca V, Ambrosini M, Taieb J, Cohen R, Lonardi S, Boursi B, Margalit O, Salvatore L, Ros J, Sabella G, Rossi C, Tougeron D, Guimbaud R, Gallois C, Elez ME, Bergamo F, Cremolini C, Overman MJ, André T, Randon G, Pietrantonio F.   +20 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Analysis of microsatellite instability intensity in single-cell resolution with scMnT reveals tumor heterogeneity in colorectal cancer. [PDF]

Brief Bioinform
Park G, Park J.
europepmc   +1 more source

Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy

MedComm, Volume 7, Issue 8, August 2026.
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge, Dong Han, Jing Wang, Xinyu Dai, Chen Ma, Feihong Chen   +5 more
wiley   +1 more source

Correction: Machine learning-based radiomics approach assessing preoperative non-contrast CT for microsatellite instability prediction in colon cancer. [PDF]

Front Physiol
Ren D, Wang Y, Chen L, He J, Shen T.
europepmc   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source