Results 181 to 190 of about 89,952 (300)

Multi‐Transcriptomic Analysis Reveals That EREG‐Driven TME Crosstalk Defines Anti‐EGFR Response in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
A multi‐transcriptomic analysis reveals the “EREG/EGFR/CSF axis” as a key intercellular network in the tumor microenvironment that dictates anti‐EGFR sensitivity in colorectal cancer. ABSTRACT Sidedness influences colorectal cancer (CRC) prognosis and treatment response, yet the mechanism dictating differential EGFR inhibitor (EGFRI) sensitivity is ...
Atsuki Taniguchi, Shunsuke Kagawa, Shohei Nogi, Tomohiko Yagi, Nobuhiko Kanaya, Shinji Kuroda, Satoru Kikuchi, Yoshihiko Kakiuchi, Hiroshi Tazawa, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source

Improving the performance of polymerase chain reaction for microsatellite instability testing in endometrial cancer. [PDF]

Sci Rep
Mendiola M, Heredia-Soto V, Baillo A, Ruz-Caracuel I, Mena R, Berjón A, Escudero FJ, Pedregosa J, Hernandez A, Feliu J, Hardisson D, Redondo A.   +11 more
europepmc   +1 more source

TYRO3, AXL, MERTK and Their Ligands in Brain Metastases From Colorectal Cancers

Cancer Medicine, Volume 15, Issue 5, May 2026.
TYRO3, AXL, and MERTK are expressed in primary tumors and extra‐cerebral and brain metastases from colorectal cancers. AXL, primarily expressed in endothelial cells, is the more conserved marker between primary tumor and brain metastasis. The Low AXL/High GAS6 ratio is of poor prognosis in metastatic colorectal cancer patients.
Anaïs Noblanc, Fatima Dkhissi, Pierre‐Olivier Guichet, Lucie Lebeau, Serge Milin, Sheik Emambux, Pauline Roussille, Camille Evrard, Lucie Karayan‐Tapon, David Tougeron, Omar Benzakour, Violaine Randrian   +11 more
wiley   +1 more source

Analysis of microsatellite instability intensity in single-cell resolution with scMnT reveals tumor heterogeneity in colorectal cancer. [PDF]

Brief Bioinform
Park G, Park J.
europepmc   +1 more source

Efficacy of Fertility‐Sparing Treatment With Progestin Is Associated With Different Molecular Classification in Endometrial Carcinoma and Atypical Endometrial Hyperplasia

Cancer Medicine, Volume 15, Issue 5, May 2026.
Molecular profiles and outcomes of CR rate in 74 cases. ABSTRACT Objective To investigate the impact of various molecular characteristics on the outcomes of fertility‐preserving therapy in patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH).
Xue‐Qian Qian, Hao‐Hui Fu, Xiao‐Yun Wan, Dong‐Xiao Hu, Yuan‐Ming Shen   +4 more
wiley   +1 more source

Comprehensive machine learning analysis of a radiomics-based model for predicting microsatellite instability in right Colon Cancer. [PDF]

Front Oncol
Li J, Liu L, Zhong X, Yang R, Wang W, Yin L, Li D, Liu H.   +7 more
europepmc   +1 more source

Efficacy of Hepatic Artery Infusion Chemotherapy Combined With Regorafenib and Sintilimab Versus Regorafenib Alone in MSS/pMMR Colorectal Cancer Liver Metastases After Second‐Line Treatment Failure

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer liver metastases (CRCLM) have limited treatment options after failure of second‐line systemic therapies. Hepatic artery infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy may offer improved outcomes.
Ran You, Qingyu Xu, Lixing Wang, Bin Leng, Chendong Wang, Zeyu Yu, Ya Lu, Lingfeng Diao, Yi Lu, Guowen Yin   +9 more
wiley   +1 more source

Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer. [PDF]

Target Oncol
Nero C, Salvatore L, Duranti S, Anderson G, Mastrantoni L, Karimi M, Mantini G, Minucci A, Maneri G, Giacò L, Santoro A, Panfili A, Piermattei A, Marino I, Caira G, Calegari MA, Trovato G, Iacobelli V, Salutari V, Normanno N, Fanfani F, Scambia G, Tortora G.   +22 more
europepmc   +1 more source

Feasibility Study of Trifluridine/Tipiracil and Zolbetuximab as Third‐ or Later‐Line Chemotherapy for CLDN18.2‐Positive and HER2‐Negative Gastric or Gastroesophageal Junction Adenocarcinoma: A Study Protocol

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Zolbetuximab is an anti‐claudin18.2 (CLDN18.2) antibody, and the addition of zolbetuximab in combination with fluoropyrimidine and oxaliplatin as a first‐line treatment for CLDN18.2‐positive and HER2‐negative gastric or gastroesophageal junction adenocarcinoma has been shown to improve survival.
Osamu Maeda, Chie Tanaka, Kazuhiro Furukawa, Kazushi Miyata, Dai Shimizu, Shizuki Sugita, Koki Nakanishi, Takashi Hirose, Kazuyuki Mizuno, Fumie Kinoshita, Yachiyo Kuwatsuka, Masahiko Ando, Mitsuro Kanda, Hiroki Kawashima, Yuichi Ando   +14 more
wiley   +1 more source

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence largely driven by human papillomavirus (HPV) infection. Despite advances in multimodal treatment, disease recurrence remains common and limits long‐term survival, highlighting the need for reliable ...
Yunxia Chen, Wenyu Zhang, Xiang Gao, Kongling Xing, Yijing Ren, Jinyu Hu, Zhihao Xie, Ping Zhou   +7 more
wiley   +1 more source