Results 181 to 190 of about 62,250 (302)

Mutations Targeted by Nous-209 Immunotherapy Occur Early in Lynch Syndrome Carriers' Precancer Lesions with Microsatellite Instability. [PDF]

Cancer Prev Res (Phila)
Micarelli E, De Marco L, Spaggiari P, D'Alise AM, Dal Buono A, Menini M, Giatti V, D'Aprano A, Scarselli E, Hassan C, Repici A.   +10 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Intratumoral heterogeneity in microsatellite instability status at single-cell resolution. [PDF]

iScience
Anthony H, Seoighe C.
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Radiomics for predicting microsatellite instability-high status in colorectal cancer: a systematic review and meta-analysis. [PDF]

World J Surg Oncol
Gou Q, He X, Zhang X.
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Correction: Radiomics analysis of multi-sequence MR images for predicting microsatellite instability status preoperatively in rectal cancer. [PDF]

Front Oncol
Li Z, Dai H, Liu Y, Pan F, Yang Y, Zhang M.   +5 more
europepmc   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Prognostic and Treatment-Associated Survival Effects of Microsatellite Instability Across Disease Stages in Colon Cancer: An NCDB Analysis. [PDF]

J Gastrointest Cancer
El Sayed M, Youssef S, Chaccour M, Harati ME.   +3 more
europepmc   +1 more source

Genomic Variation and Population Structure of Portuguese Native Dog Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The presence of dogs in Portugal is confirmed by zooarchaeological evidence dating to at least 7600 years ago. The 11 native dog breeds that exist in this territory are therefore the end‐product of a complex evolutionary process. This study characterises the genomic diversity and population structure of 10 native breeds based on whole‐genome ...
Ludmilla Blaschikoff, Octávio Serra, Fernanda Simões, Catarina Ginja, Ana Elisabete Pires   +4 more
wiley   +1 more source