Results 191 to 200 of about 62,250 (302)

Comparison of immunohistochemistry, PCR, and NGS for the evaluation of mismatch repair deficiency and microsatellite instability in colorectal cancer: a retrospective study. [PDF]

Diagn Pathol
Wang L, Hu Y, Yuan H, Yu N, Xiao L, Jin J.   +5 more
europepmc   +1 more source

Long‐term demography and spatial genetic structure reveal mechanisms of Sassafras albidum population persistence through clonality

American Journal of Botany, Volume 113, Issue 6, June 2026.
Abstract Premise Vegetative regeneration is a key mechanism of woody plant persistence in forest ecosystems, and the coupled roles of basal sprouting and clonal growth in shaping long‐term population dynamics have been understudied. Basal sprouting replaces stems at fixed ramet locations, whereas clonal growth via root suckering produces spatially ...
J. T. Michel, Jonathan P. Evans, Skyler J. Fox, Ashley B. Morris   +3 more
wiley   +1 more source

Checkpoint inhibitors in microsatellite instability-high metastatic colorectal cancer: treatment strategies, specificities, and care management questions. [PDF]

ESMO Gastrointest Oncol
André T, Lonardi S, Zaanan A, Cohen R, Taieb J.   +4 more
europepmc   +1 more source

Zebrafish as an Anti‐Isogenic Vertebrate Model and What It Reveals About Genetic Background and Reproducibility

BioEssays, Volume 48, Issue 6, June 2026.
Zebrafish illustrates how polygenic sex determination, maternal germline bottlenecks, and a structurally restless genome jointly destabilize deep homozygosity. These interlocking constraints make fully isogenic zebrafish lines effectively unattainable, turning this model into a natural “stress test” for assumptions about genetic background and ...
Álvaro J. Arana, Laura Sánchez
wiley   +1 more source

The Role of Microsatellite Instability in Endometrial Hyperplasia and Risk of Carcinoma Development. [PDF]

Biomedicines
Mollova-Kyosebekirova A, Uchikova E, Mihaylova A, Koleva-Ivanova M, Parahuleva M, Parahuleva N.   +5 more
europepmc   +1 more source

Treatment Advances in Gynecologic Cancers: Insights From Recent Clinical Trials

Cancer Innovation, Volume 5, Issue 3, June 2026.
Overview of immunotherapy and antibody‐drug conjugates, and their mechanism against cancer. (The Graphical Abstract Image was created with BioRender.) ABSTRACT Gynecologic cancers remain a major global health burden for women. Their management has evolved toward a gynecologic oncologist‐led multimodal paradigm.
Yiyang Shen, Xiaofei Jiao, Yuanjia Wen, Zikun Peng, Xuejiao Zhao, Jiahao Liu, Qinglei Gao   +6 more
wiley   +1 more source

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non-Smokers and Non-Drinkers. [PDF]

J Oral Pathol Med
Mulder FJ, Gielgens TFB, de Ruiter EJ, de Bree R, van den Hout MFCM, Kremer B, Willems SM, Speel EJM.   +7 more
europepmc   +1 more source

Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large‐Scale Genomic Analysis of 1094 Patients

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective To investigate the prevalence, characteristics, and clinical implications of germline mutations in a consecutive cohort of Chinese colorectal cancer (CRC) patients, providing insights that may inform population‐specific genetic testing strategies.
Liting Lu, Xinyu Peng, Jiaxin Zhang, Yixin Ding, Junliang Lu, Hengxue Lin, Huanwen Wu, Xicheng Wang, Yi Ba   +8 more
wiley   +1 more source

Analysis of DNA mismatch repair and microsatellite instability in molecular typing of endometrial carcinoma. [PDF]

Discov Oncol
Li NM, Cheng HP, Zhou P, Li XH.
europepmc   +1 more source

Studying When to Add Biological Therapy to Cytotoxic Therapy in Advanced Cancer Care Using Real World Data: How to Avoid Design Choices That Generate Immortal Time

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Since real‐world data lack information on treatment assignment (usually the only information available is treatment prescription/administration) and early outcomes can happen in advanced cancer, some design choices may introduce immortal time due to selection or due to treatment strategy misclassification.
Xabier Garcia‐Albeniz, Julia Vila‐Guilera, Manuel Zamparini, Helena Oliveres, Vicente Alonso‐Orduna, Jaime Feliu, Ana Fernández‐Montes, Marta Martín‐Richard, Elisa Gálvez‐Munoz, Ana Ruiz‐Casado, Alfonso Yubero‐Esteban, Jorge Aparicio, Julia Alcaide‐Garcia, Javier Gallego Plazas, Carlos Fernandez‐Martos, Rosa Gallego‐Sanchez, Mónica Guillot Morales, Rubén Leno, Francis Esposito, Sandra Lopez‐Prades, Míriam Cuatrecasas, Barbra A. Dickerman, Joan Maurel   +22 more
wiley   +1 more source