Results 191 to 200 of about 89,952 (300)

Diagnostic Challenges and Clinical Implications of Microsatellite Instability/Mismatch Repair Deficiency in Solid Tumors. [PDF]

Cancer Res Treat
Kwak Y, Bae JM, Lee HS.
europepmc   +1 more source

Characterisation of tumor‐infiltrating gamma‐delta T cells in human colorectal cancer with MHC‐I loss

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives Gamma‐delta (γδ) T cells have been associated with favorable prognoses across several malignancies, underscoring their potential as targets for novel immunotherapies. These unconventional T lymphocytes exhibit an intrinsic tropism for the tumor microenvironment, largely driven by their capacity to recognize stress‐induced antigens ...
Tianming A Li, Luke T Quigley, Kok Fei Chan, David S Williams, Lisa A Mielke, Andreas Behren, Jessica Da Gama Duarte   +6 more
wiley   +1 more source

<i>Bacteroides fragilis</i> toxin in colorectal tumors activates STAT3 and drives microsatellite instability. [PDF]

Ann Med Surg (Lond)
Mehmood MS, Danaf N.
europepmc   +1 more source

Efficacy and safety of disitamab vedotin (RC48) combined with camrelizumab and S‐1 for neoadjuvant therapy of locally advanced gastric cancer with HER2‐overexpressing: Preliminary results of a prospective, single‐arm, phase II study

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Neoadjuvant disitamab vedotin combined with camrelizumab and S‐1 achieved high pathological response rates with manageable safety in resectable HER2‐overexpressing gastric and gastroesophageal junction cancer. Longitudinal circulating tumour DNA methylation profiling enabled dynamic monitoring of molecular response during treatment.
Longgang Wang, Bing Liu, Luguang Liu, Liqing Liu, Rong Li, Shumei Han, Xu Sun, Bo Bi, Yuanlin Sun, Dong Sun, Jie Chai   +10 more
wiley   +1 more source

Study on predicting microsatellite instability in rectal cancer using T₂ mapping combined with ADC value. [PDF]

Cancer Imaging
Zhao X, Hou Y, Ma H.
europepmc   +1 more source

A multi‐centre, prospective trial of a methylation‐based liquid biopsy for early detection of liver cancer in high‐risk populations

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Three hypermethylated cfDNA markers specific to liver cancer, RNF135, CHFR and PAX5, were identified in peripheral blood and used to construct a diagnostic model. The model achieved 94.43% sensitivity and 95.16% specificity in a large clinical validation cohort, with a sensitivity of 93.1% for stage‐I liver cancer. Abstract Background and aims Existing
Ruohan Zhang, Xinrong Yang, Guangming Li, Yinan Deng, Jibing Liu, Hongjun Gao, Jie Zhao, Jianwen Cheng, Xiaofei Zhao, Yang Yang, Zhen Wu, Shuangzhen Gu, Yang Wu, Zhongying Ma, Yanli Liu, Yan Kang, Guangpeng Zhou, Hua Li, Yonghong Zhang, Xiaoliang Han, Jia Fan, Jian Zhou, Kefeng Dou, Kaishan Tao   +23 more
wiley   +1 more source

Clinical characteristics of endometrial cancers with microsatellite instability-high and <i>BRCA1/2</i> mutations. [PDF]

Front Oncol
Shan Y, Wang Y, Huang L, Li G, Cui Z, Xing X, Yin G.   +6 more
europepmc   +1 more source

Analysis of Somatic Mutations and Immunotherapy Biomarkers in Chinese Patients With Non‐Small Cell Lung Cancer During 2019–2024: A Retrospective Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Understanding genetic alterations in lung cancer remains challenging due to tumor heterogeneity and malignancy. This study aimed to investigate somatic variations and immune‐related biomarkers in Chinese patients with NSCLC.
Xiumei Liu, Weigong Chen, Chengqi Xin, Zexu Wang, Kaiyu Yi, Liang Wang, Jing Liu   +6 more
wiley   +1 more source

Efficacy of Immune Checkpoint Blockade in Advanced Upper Tract Urothelial Cancer With DNA Mismatch Repair Deficiency or Microsatellite Instability. [PDF]

JCO Precis Oncol
Moussa MJ, Andreev-Drakhlin AY, Venkatesan AM, Matin SF, Xiao L, Tidwell RSS, Shah AY, Adriazola AC, Shaw L, Gao J, Lin JK, Goswami S, Msaouel P, Guo CC, Tannir NM, Siefker-Radtke AO, Alhalabi O, Campbell MT.   +17 more
europepmc   +1 more source

Peripheral Blood Biomarkers Predict Outcomes in Advanced Cancers Treated With Anti‐PD‐1 Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
This study identifies dNLR≤ 3.18, AMC ≤ 0.48, IL‐6 ≤ 12.35, and squamous histology as independent predictors of improved survival in advanced cancers treated with anti‐PD‐1 therapy. A novel biomarker‐based model demonstrates high accuracy for 1‐year survival stratification, aiding clinical decision‐making.
Chunxia Feng, Ping Li, Qianhui Gu, Minbin Chen, Jinhua Gu   +4 more
wiley   +1 more source