Results 211 to 220 of about 89,952 (300)

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Identifying actionable genetic mutations and microsatellite instability in liquid biopsy of colorectal cancer. [PDF]

J Genet Eng Biotechnol
Kassem NM, Seadawy MG, Gaafar M, Kassem HA, Ahmed Hussein AF, Ali Rizk EM, Hassan MA, AbdelAziz RH, Abdelradi MM, El-Hosseny MF, Abdulla M, Moneim RA.   +11 more
europepmc   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer. [PDF]

World J Gastrointest Surg
Qu HD, Gao X, Xiao P, Jiao Y.
europepmc   +1 more source

Genomic and Clinical Impact of Smoking on Therapeutic Outcomes in Prostate Cancer: A Public Databases Analysis

The Prostate, Volume 86, Issue 6, Page 689-696, May 2026.
ABSTRACT Background In prostate cancer (PCa), smoking history is associated with more aggressive clinicopathological features, reduced efficacy of androgen deprivation therapy, and poorer overall survival (OS). However, its impact on survival outcomes in patients receiving taxane chemotherapy, poly ADP‐ribose polymerase inhibitor (PARPi), or immune ...
Tomoya Hatayama, Yohei Sekino, Go Kobayashi, Kazuma Yukihiro, Yoshinori Nakano, Shinsaku Tasaka, Naofumi Nomura, Yuki Kohada, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata   +16 more
wiley   +1 more source

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis. [PDF]

JNCI Cancer Spectr
Saqi IK, Nielsen AT, Madsen MT, Gögenur I, Orhan A, Justesen TF.   +5 more
europepmc   +1 more source

Quantum Protocol Architectures and Secure Control Frameworks For 7G+ Networks: Standards, Synchronization, Use Cases, and Challenges

Advanced Quantum Technologies, Volume 9, Issue 5, May 2026.
ABSTRACT Quantum‐native communication systems are reshaping secure, programmable, and coherence‐aware networking beyond the classical paradigm. As intelligent physical infrastructures, ranging from unmanned aerial vehicle swarms to satellite Quantum Key Distribution (QKD) platforms, demand trust, synchronization, and ultra‐reliability, conventional ...
Shakil Ahmed, Ibrahim Almazyad, Ashfaq Khokhar   +2 more
wiley   +1 more source

Microsatellite Instability Status and Mismatch Repair Defects Testing in Endometrial Cancer-Insights from the Multicenter E-PEC Trial. [PDF]

Diagnostics (Basel)
Eser B, Papior D, Salmanton-García J, Cornely OA, Morgenstern B, Herpel C, Radosa JC, Almuheimid A, Aktas B, Weydandt L, Wittenborn J, Meyer-Wilmes P, Friebe V, Leidinger C, Kimmig R, Thangarajah F.   +15 more
europepmc   +1 more source

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials [PDF]

, 2017
et al,, Mutch, David G
core   +1 more source