Results 221 to 230 of about 62,250 (302)

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Study on predicting microsatellite instability in rectal cancer using T₂ mapping combined with ADC value. [PDF]

Cancer Imaging
Zhao X, Hou Y, Ma H.
europepmc   +1 more source

Radiomics: Current Applications and Future Directions

MedComm, Volume 7, Issue 6, June 2026.
Radiomics enables high‐throughput extraction of quantitative imaging features to decode tumor phenotypes across solid tumors. This panoramic review summarizes its technical pipeline, standardization strategies, pan‐cancer clinical applications, and translational bottlenecks.
Jiangbo Shao, Meng Wei, Ke Li, Guangchao Lv, Kai Liu, Ye Guo   +5 more
wiley   +1 more source

Clinical characteristics of endometrial cancers with microsatellite instability-high and <i>BRCA1/2</i> mutations. [PDF]

Front Oncol
Shan Y, Wang Y, Huang L, Li G, Cui Z, Xing X, Yin G.   +6 more
europepmc   +1 more source

Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer

MedComm, Volume 7, Issue 6, June 2026.
This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu   +11 more
wiley   +1 more source

A Deep Learning-Based Approach for Explainable Microsatellite Instability Detection in Gastrointestinal Malignancies. [PDF]

J Imaging
Ciardiello L, Agnello P, Petyx M, Martinelli F, Cesarelli M, Santone A, Mercaldo F.   +6 more
europepmc   +1 more source

Genetic Alterations in the SERPIN Gene Family as Predictors of Immune Checkpoint Therapy Efficacy in Melanoma and Non‐Small Cell Lung Cancer

Medicine Advances, Volume 4, Issue 2, Page 235-245, June 2026.
This study demonstrated a clear association between serine protease inhibitor (SERPIN) gene alterations and clinical outcomes in patients with melanoma and non‐small cell lung cancer receiving immune checkpoint inhibitor therapy across five cohorts.
Jieqiong Li, Di Wang, Yuxin Wang, Lixia Wang, Jinmei Luo, Yi Xiao   +5 more
wiley   +1 more source

Efficacy of Immune Checkpoint Blockade in Advanced Upper Tract Urothelial Cancer With DNA Mismatch Repair Deficiency or Microsatellite Instability. [PDF]

JCO Precis Oncol
Moussa MJ, Andreev-Drakhlin AY, Venkatesan AM, Matin SF, Xiao L, Tidwell RSS, Shah AY, Adriazola AC, Shaw L, Gao J, Lin JK, Goswami S, Msaouel P, Guo CC, Tannir NM, Siefker-Radtke AO, Alhalabi O, Campbell MT.   +17 more
europepmc   +1 more source

Postoperative Chemotherapy in Stage IIA Gastric Cancer: Not Always Necessary

Medicine Advances, Volume 4, Issue 2, Page 246-252, June 2026.
Postoperative chemotherapy (POCT) in stage IIA gastric cancer was associated with improved overall survival but did not significantly improve disease‐specific survival after propensity score matching. The benefit of POCT varied across subgroups, with limited benefit in patients with favorable tumor biology and potential benefit in higher‐risk patients.
Yuan Zheng, Di Zhang, Hossein Mehrabanidil, Jiaoyang Lu   +3 more
wiley   +1 more source