Results 251 to 260 of about 89,952 (300)

Successful treatment with pembrolizumab for microsatellite instability-high thymic carcinoma: A case report. [PDF]

Respir Med Case Rep
Sakamori Y, Hamada K, Kawachi H, Yamoto M, Fukao A, Terashita S, Watanabe K, Ikeue T, Sugita T.   +8 more
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Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer. [PDF]

Clin Cancer Res
Sayegh N, Graf RP, Swami U, Ozay ZI, Hage Chehade C, Elvin JA, Lin D, Quintanilha JCF, Li G, Bryce AH, McKay RR, Ross JS, Zhang T, Agarwal N.   +13 more
europepmc   +1 more source

Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome. [PDF]

Cancer Med
Vargas-Castellanos E, Rincón-Riveros A.
europepmc   +1 more source

Integrating nutritional and inflammatory biomarkers in colorectal cancer management: Implications of microsatellite instability status. [PDF]

World J Gastrointest Surg
Xie RX, Xing YX, Sun NZ.
europepmc   +1 more source

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Microsatellite instability: an update

Archives of Toxicology, 2015
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Hiroyuki, Yamamoto, Kohzoh, Imai
openaire   +2 more sources

Microsatellite instability

Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Y R, Parc, K C, Halling
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Detection of Microsatellite Instability

2003
In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER).
K D, Berg, C A, Griffin, J R, Eshleman
openaire   +2 more sources

Microsatellite Instability in Hematological Malignancies

Leukemia & Lymphoma, 2002
The replication error (RER+) phenotype, characterized by microsatellite instability (MSI) has been recently related to mutations of genes involved in DNA mismatch repair pathway. These genetic alterations were first described in hereditary non polyposis colorectal cancer (HNPCC). We examined 44 patients with hematological malignancies (27 AML, 9 MDS, 2
Lenka, Krsková-Honzátková, Jaroslav, Cermák, Jana, Sajdová, Jan, Starý, Petr, Sedlácek, Zuzana, Sieglová   +5 more
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