Results 261 to 270 of about 89,952 (300)

Microsatellite instability in esophageal adenocarcinoma

Cancer Letters, 2004
The frequency of microsatellite instability (MSI), a result of defective mismatch repair during DNA replication, has been reported inconsistently in primary esophageal adenocarcinoma (EADC). Using a panel of 15 markers, the primary aim of this study was to analyze the frequency of MSI in a well-characterized series of 27 primary EADCs, defined ...
Susan C, Evans, Amy, Gillis, Laurette, Geldenhuys, Nadine M, Vaninetti, Dickran A, Malatjalian, Geoffrey A, Porter, Duane L, Guernsey, Alan G, Casson   +7 more
openaire   +2 more sources

Microsatellite instability in oral cancer

International Journal of Cancer, 1995
AbstractGeneralized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability.
C S, Ishwad, R E, Ferrell, K M, Rossie, B N, Appel, J T, Johnson, E N, Myers, J C, Law, S, Srivastava, S M, Gollin   +8 more
openaire   +2 more sources

Microsatellite instability associated with hepatocarcinogenesis

Journal of Hepatology, 1999
The biological and clinicopathological significance of microsatellite instability in hepatocellular carcinoma still remains to be determined. The aim of this study was to assess the role of microsatellite instability in hepatocarcinogenesis.Genomic DNA extracted from 38 fresh samples of hepatocellular carcinoma was amplified by polymerase chain ...
Yutaka Kondo, Yae Kanai
exaly   +3 more sources

Microsatellite instability in uterine sarcomas

International Journal of Gynecological Cancer, 2001
Studies have shown a 15-30% frequency of microsatellite instability in endometrial cancer. In addition, we found a 21% frequency of microsatellite instability in endometrial cancer. Our aim was to investigate the presence of microsatellite instability and loss of heterozygosity in uterine sarcomas.
Amant, F., Dorfling, C. M., Dreyer, L., Vergote, I., Lindeque, B. G., van Rensburg, E. J.   +5 more
openaire   +2 more sources

Microsatellite instability in cervical carcinoma

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.A retrospective study of 100 cases of cervical carcinoma.MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical
T K, Chung, T Y, Ip, G M, Hampton, V W, Wang, T H, Cheung, Y F, Wong   +5 more
openaire   +2 more sources

Microsatellite instability in colorectal adenomas

Gastroenterology, 1997
Microsatellite instability in apparently sporadic, predominantly right-sided colon cancers seems to be the result of an acquired, rather than germline, genetic change that impairs mismatch repair. The timing of this change with respect to the adenomacarcinoma sequence has not been determined.
W S, Samowitz, M L, Slattery
openaire   +2 more sources

Microsatellite DNA Instability in COPD

Chest, 1999
Cigarette smoking is the prime cause of COPD; however, only a few smokers develop the disease. In a previous study, we demonstrated that microsatellite DNA instability (MSI) is a detectable phenomenon in sputum cells of COPD patients. Therefore, we hypothesize that this genetic alteration may indicate susceptibility to COPD.In order to investigate this
N M, Siafakas, E G, Tzortzaki, G, Sourvinos, D, Bouros, N, Tzanakis, A, Kafatos, D, Spandidos   +6 more
openaire   +2 more sources

Microsatellite instability in breast cancer

Annals of Surgical Oncology, 1997
Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of primary breast carcinoma surgical specimens.Using
E B, Rush, J E, Calvano, K J, van Zee, A D, Zelenetz, P I, Borgen   +4 more
openaire   +2 more sources

Microsatellite instability: Advances in diagnosis

Cancer
The authors discuss current standard approaches to mismatch repair/microsatellite instability assessment, as well as emerging approaches, in the context of a new study from Thomas et al. on a novel machine learning approach, MIAmS.
Patrick M. Boland, Shridar Ganesan
openaire   +2 more sources

Microsatellite Instability in Hematologic Malignancies

Leukemia & Lymphoma, 1997
Malignant transformation in humans occurs via different mechanisms including the activation of oncogenes and/or loss of tumor suppressor genes. Recently, DNA mismatch repair defects manifest as genome wide microsatellite instability have been described as an additional mechanism of tumorgenesis in humans.
openaire   +2 more sources