Results 261 to 270 of about 62,250 (302)

Microsatellite instability: an update

Archives of Toxicology, 2015
Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Hiroyuki, Yamamoto, Kohzoh, Imai
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Microsatellite instability

Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Detection of Microsatellite Instability

2003
In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER).
K D, Berg, C A, Griffin, J R, Eshleman
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Microsatellite Instability Testing

2003
Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Y R, Parc, K C, Halling
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Microsatellite Instability in Hematological Malignancies

Leukemia & Lymphoma, 2002
The replication error (RER+) phenotype, characterized by microsatellite instability (MSI) has been recently related to mutations of genes involved in DNA mismatch repair pathway. These genetic alterations were first described in hereditary non polyposis colorectal cancer (HNPCC). We examined 44 patients with hematological malignancies (27 AML, 9 MDS, 2
Lenka, Krsková-Honzátková, Jaroslav, Cermák, Jana, Sajdová, Jan, Starý, Petr, Sedlácek, Zuzana, Sieglová   +5 more
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Microsatellite instability in esophageal adenocarcinoma

Cancer Letters, 2004
The frequency of microsatellite instability (MSI), a result of defective mismatch repair during DNA replication, has been reported inconsistently in primary esophageal adenocarcinoma (EADC). Using a panel of 15 markers, the primary aim of this study was to analyze the frequency of MSI in a well-characterized series of 27 primary EADCs, defined ...
Susan C, Evans, Amy, Gillis, Laurette, Geldenhuys, Nadine M, Vaninetti, Dickran A, Malatjalian, Geoffrey A, Porter, Duane L, Guernsey, Alan G, Casson   +7 more
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Microsatellite instability in oral cancer

International Journal of Cancer, 1995
AbstractGeneralized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability.
C S, Ishwad, R E, Ferrell, K M, Rossie, B N, Appel, J T, Johnson, E N, Myers, J C, Law, S, Srivastava, S M, Gollin   +8 more
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Microsatellite DNA Instability in COPD

Chest, 1999
Cigarette smoking is the prime cause of COPD; however, only a few smokers develop the disease. In a previous study, we demonstrated that microsatellite DNA instability (MSI) is a detectable phenomenon in sputum cells of COPD patients. Therefore, we hypothesize that this genetic alteration may indicate susceptibility to COPD.In order to investigate this
N M, Siafakas, E G, Tzortzaki, G, Sourvinos, D, Bouros, N, Tzanakis, A, Kafatos, D, Spandidos   +6 more
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Microsatellite instability in cervical carcinoma

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.A retrospective study of 100 cases of cervical carcinoma.MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical
T K, Chung, T Y, Ip, G M, Hampton, V W, Wang, T H, Cheung, Y F, Wong   +5 more
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Microsatellite instability in colorectal adenomas

Gastroenterology, 1997
Microsatellite instability in apparently sporadic, predominantly right-sided colon cancers seems to be the result of an acquired, rather than germline, genetic change that impairs mismatch repair. The timing of this change with respect to the adenomacarcinoma sequence has not been determined.
W S, Samowitz, M L, Slattery
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