Results 241 to 250 of about 62,250 (302)

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer. [PDF]

World J Gastrointest Surg
Qu HD, Gao X, Xiao P, Jiao Y.
europepmc   +1 more source

Long‐Term Colorectal Cancer Incidence After Adenoma and Serrated Polyp Removal: Results From the Colonprev Trial

United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.
ABSTRACT Background The risk of colorectal cancer (CRC) after serrated polyp resection remains unclear, and current surveillance recommendations rely on limited evidence. We evaluated CRC incidence in individuals with advanced serrated lesions (ASL) detected at baseline colonoscopy and compared risk according to the most advanced lesion identified ...
Joaquín Cubiella, Carme García‐Benito, Antoni Castells, Enrique Quintero, Luis Bujanda, Susana Castán‐Cameo, José Díaz‐Tasende, Ángel Lanas, Akiko Ono, Eladio Frías‐Arrocha, Cristina Hernández, Rodrigo Jover, Montserrat Andreu, Fernando Carballo, Juan Diego Morillas, Dolores Salas, Cristina Regueiro‐Expósito, Pedro Davila‐Piñón, Astrid Diez‐Martín, on behalf of the COLONPREV study investigators   +19 more
wiley   +1 more source

Identifying actionable genetic mutations and microsatellite instability in liquid biopsy of colorectal cancer. [PDF]

J Genet Eng Biotechnol
Kassem NM, Seadawy MG, Gaafar M, Kassem HA, Ahmed Hussein AF, Ali Rizk EM, Hassan MA, AbdelAziz RH, Abdelradi MM, El-Hosseny MF, Abdulla M, Moneim RA.   +11 more
europepmc   +1 more source

Predictive Immunohistochemistry in Cholangiocarcinoma: Current Clinical Utility, Practical Limitations, and Emerging Directions

APMIS, Volume 134, Issue 6, June 2026.
ABSTRACT Cholangiocarcinoma (CCA) remains a difficult‐to‐treat biliary malignancy in which therapeutic stratification increasingly depends on predictive biomarkers. Although next‐generation sequencing is essential for the detection of targetable genomic alterations, immunohistochemistry (IHC) retains a practical role because it is widely available ...
Francesco Vasuri, Alessandra Boccaccino, Stefano Tamberi, Luca Saragoni   +3 more
wiley   +1 more source

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis. [PDF]

JNCI Cancer Spectr
Saqi IK, Nielsen AT, Madsen MT, Gögenur I, Orhan A, Justesen TF.   +5 more
europepmc   +1 more source

Macrophage‐Specific Loss of Stearoyl‐CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization

Cancer Science, Volume 117, Issue 6, Page 1566-1579, June 2026.
Macrophage‐specific Scd1 deletion accelerates colon cancer progression by suppressing the Hippo‐YAP pathway, which drives immunosuppressive M2 polarization and induces CD8+ T cell exhaustion. Pharmacological YAP activation with TT‐10 effectively reverses this microenvironment, highlighting a promising target for immunotherapy. ABSTRACT In colon cancer (
Qing You, Jiaqi Du, Ziran Wei, Yandong Liu, Weijun Wang, Wenchao Gao   +5 more
wiley   +1 more source

Microsatellite Instability Status and Mismatch Repair Defects Testing in Endometrial Cancer-Insights from the Multicenter E-PEC Trial. [PDF]

Diagnostics (Basel)
Eser B, Papior D, Salmanton-García J, Cornely OA, Morgenstern B, Herpel C, Radosa JC, Almuheimid A, Aktas B, Weydandt L, Wittenborn J, Meyer-Wilmes P, Friebe V, Leidinger C, Kimmig R, Thangarajah F.   +15 more
europepmc   +1 more source

Immune Checkpoint Inhibition as a Novel Strategy for Microsatellite Instability-High Duodenal Adenocarcinoma: A Report of Three Cases. [PDF]

Surg Case Rep
Shirabe K, Kawazoe T, Harima T, Nambara S, Tsuda Y, Nakanoko T, Ando K, Oki E, Yoshizumi T.   +8 more
europepmc   +1 more source

Prediction of Microsatellite Instability in Colorectal Cancer Using Two Internally Validated Radiomic Models. [PDF]

Tomography
Galluzzo A, Danti G, Calistri L, Cozzi D, Lavacchi D, Rossini D, Antonuzzo L, Paolucci S, Castiglione F, Messerini L, Cianchi F, Miele V.   +11 more
europepmc   +1 more source