Results 121 to 130 of about 62,250 (302)

From Flybys to Sample Return: A Review of Space Probes and Robotic Sampling Technologies for Small Bodies

Journal of Field Robotics, EarlyView.
ABSTRACT As a crucial puzzle piece of deep space exploration, exploring small bodies can provide significant scientific insights and valuable mineral resources. Unlike missions to the Moon and Mars, small‐body missions pose distinct technical challenges, including communication delays, weak gravity, and uncertain environments. This paper reviews a full
Xin Zhang, Hao Zhou, Dalin Zhou, Zhaojie Ju   +3 more
wiley   +1 more source

Human Blood‐Brain Tumor Barrier on a Chip to Investigate Personalized Treatment for Glioblastoma Patients

Small, EarlyView.
A microfluidic model of the glioblastoma (GBM) margin was developed to mimic patient‐specific blood‐brain tumor barrier (BBTB) function and drug response. The platform revealed inter‐patient variability in barrier integrity and drug sensitivity, offering a tool for personalized therapy evaluation in GBM.
Minsu Ryoo, Gaeun Lee, Jinwoo Jung, Sujin Cho, Sharon Jeeho Ham, Nayeong Kang, Hyeongjin Ahn, Yu Jin Kim, JeongMin Sim, Jeongman Park, Juwon Kim, Sohyun Hwang, Jihwan Yoo, Youn‐Jung Kang, Jaejoon Lim, Jungho Ahn, Song Ih Ahn   +16 more
wiley   +1 more source

Evaluating the Role of Genetic Markers in Predicting Oral Leukoplakia Malignancy Transformation

Journal of Pharmacy and Bioallied Sciences
Background: Oral leukoplakia is a common premalignant lesion in the oral cavity, with varying risks of transformation into oral squamous cell carcinoma (OSCC).
Ahtesham Ahmad Qurishi, Mohamed S. Mohamed Morsy, Abeer M. Atout, Shahad Essa Abzoah, Mohammed Hasan M. Wadani, Nawaf Hussain Ali Ghazwani, Shatha Ahmad Mohammad Jafari   +6 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Evaluation of Microsatellite instability score from GMS560 DNA panel [Elektronisk resurs]

, 2022
Microsatellite instability is characterised by gains or losses of nucleotides in short tandem repeat sequences, microsatellites, dispersed throughout the human genome.
Thankaswamy, Subazini,, Levéen, Per,, Helenius, Gisela,, Koskela, Anita,, Fredriksson, Johan,, Lindqvist, Carl Mårten,, Andersson, Lina,, Green, Anna,, Holmgren, Benjamin,, Qvick, Alvida,, Isaksson, Helena S.,, Jakobsen, Ingrid,, Farkas, Sanja A.,   +12 more
core  

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Impact of RAS/RAF Mutations on Metastatic Treatment Response Following Total Neoadjuvant Therapy in Patients With Stage IV Rectal Cancer

Asia-Pacific Journal of Clinical Oncology, EarlyView.
There is limited understanding of the impact of underlying RAS/RAF mutational status on total neoadjuvant therapy metastatic tumor response rates in curative Stage IV rectal cancer patients. Complete metastatic tumor response to TNT was demonstrated in half as many mRAS as wtRAS patients and disease progression was higher in patients harboring RAS ...
Tracy R. Fitzsimmons, Z. Bunjo, E. L. Neo, A. Badiei, M. Penniment, S. Selva‐Nayagam, A. Ruszkiewicz, J. Wong, T. Sammour   +8 more
wiley   +1 more source

Microsatellite status and its correlation with clinicopathological features in gastric carcinoma: insights from a retrospective study in Northern Pretoria

Pathology and Oncology Research
Introduction/backgroundGastric carcinomas (GC) are heterogeneous malignancies characterised by distinct histological and molecular subtypes. The microsatellite instability (MSI) molecular subtype, resulting from deficient DNA mismatch repair (dMMR ...
Ntebogeng Kgokong, Ntebogeng Kgokong, Michelle McCabe, Michelle McCabe, Lucia N. Mhlongo, Lucia N. Mhlongo, Thato Nkwagatse, Thato Nkwagatse, Moshawa C. Khaba, Moshawa C. Khaba   +9 more
doaj   +1 more source

Infrequent Microsatellite Instability in Papillary Carcinomas of the Thyroid [PDF]

, 1999
The aim of the present study was to confirm the frequency of microsatellite instability in thyroid cancers. We investigated 26 patients suffering from thyroid cancer (25 papillary carcinomas, 1 follicular carcinoma) using 8 microsatellite markers ...
Yamamoto, Toshiharu
core  

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source