Results 31 to 40 of about 859,289 (399)

Microsatellite Instability and Its Clinical Significance in Endometrial Carcinoma [PDF]

Zhongguo quanke yixue, 2022
BackgroundThe role of microsatellite instability in the progression of endometrial cancer, a common cancer in women, has obtained increasing attentions in recent years.
XIAO Jing, WU Ying
doaj   +1 more source

Analysis of microsatellite instability in medulloblastoma [PDF]

Neuro-Oncology, 2009
Medulloblastoma is the most common malignant brain tumor in children. The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed. The aim of the present study was to evaluate the role of MSI in medulloblastoma carcinogenesis. MSI status was determined in 36 patients using a pentaplex
Pereira, Marta Sofia Carvalho Ribeiro Viana, Almeida, Inês, Sousa, Sónia, Mahler-Araújo, Bethânia, Seruca, Raquel, Pimentel, José, Reis, R. M.   +6 more
openaire   +4 more sources

Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E-stained images: Achieving SOTA predictive performance with fewer data using Swin Transformer [PDF]

, 2022
Artificial intelligence (AI) models have been developed for predicting clinically relevant biomarkers, including microsatellite instability (MSI), for colorectal cancers (CRC). However, the current deep-learning networks are data-hungry and require large training datasets, which are often lacking in the medical domain.
arxiv   +1 more source

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +2 more sources

Clinical-grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.

Gastroenterology, 2020
BACKGROUND AND AIMS Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR) in colorectal tumors are used to select treatment for patients.
A. Echle, H. Grabsch, P. Quirke, P. A. van den Brandt, N. West, G. Hutchins, Lara R. Heij, X. Tan, S. Richman, Jeremias Krause, E. Alwers, J. Jenniskens, K. Offermans, R. Gray, H. Brenner, J. Chang-Claude, C. Trautwein, A. Pearson, P. Boor, T. Luedde, N. Gaisa, M. Hoffmeister, Jakob Nikolas Kather   +22 more
semanticscholar   +1 more source

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Microsatellite instability in colorectal cancer

EXCLI journal, 2018
EXCLI Journal; 17:Doc159; ISSN 1611 ...
Shahin Behrouz Sharif, Shahin Behrouz Sharif, Jafar Nouri Nojadeh, Ebrahim Sakhinia   +3 more
openaire   +8 more sources

Microsatellite instability in uterine sarcomas [PDF]

International Journal of Gynecological Cancer, 2001
Studies have shown a 15-30% frequency of microsatellite instability in endometrial cancer. In addition, we found a 21% frequency of microsatellite instability in endometrial cancer. Our aim was to investigate the presence of microsatellite instability and loss of heterozygosity in uterine sarcomas.
Ignace Vergote, E. J. Van Rensburg, Frédéric Amant, L Dreyer, B. G. Lindeque, Cecelia M Dorfling   +5 more
openaire   +2 more sources

Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Haematologica, 2013
Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic ...
Terry J. Gaymes, Azim M. Mohamedali, Miranda Patterson, Nazia Matto, Alexander Smith, Austin Kulasekararaj, Rajani Chelliah, Nicola Curtin, Farzin Farzaneh, Sydney Shall, Ghulam J. Mufti   +10 more
doaj   +1 more source

Microsatellite instability: A 2024 update. [PDF]

Cancer Sci
AbstractDeficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High‐frequency MSI (MSI‐H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for immune checkpoint inhibitors (ICIs). Various methods based on next‐generation sequencing (NGS)
Yamamoto H, Watanabe Y, Arai H, Umemoto K, Tateishi K, Sunakawa Y.   +5 more
europepmc   +3 more sources