Aberrant methylation within RUNX3 CpG island associated with the nuclear and mitochondrial microsatellite instability in sporadic gastric cancers. Results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. [PDF]
, 2007 Gastric cancer (GC) development is a multistep process, during which numerous alterations accumulate in nuclear and mitochondrial DNA. A deficiency of repair machinery brings about an accumulation of errors introduced within simple repetitive ...
Agnese, V. +13 more
core +1 more source
Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite [PDF]
Genetics, 1997 One of the most common microsatellites in eukaryotes consists of tandem arrays [usually 15-50 base pairs (bp) in length] of the dinucleotide GT. We examined the rates of instability for poly GT tracts of 15, 33, 51, 99 and 105 bp in wild-type and mismatch repair-deficient strains of Saccharomyces cerevisiae. Rates of instability increased more than two
Monika Wierdl +2 more
openaire +2 more sources
Frontiers in Oncology, 2023 ObjectiveTo explore new biomarkers related to microsatellite instability in order to better predict prognosis and guide medication.MethodsThe “limma” R package was used to identify differentially expressed genes in GSE24514, and then weighted correlation
Shaorui Rui +6 more
doaj +1 more source
Frequency of Microsatellite Instability in Unselected Sebaceous Gland Neoplasias and Hyperplasias [PDF]
, 2003 Sebaceous gland neoplasias are the cutaneous manifestation of the Muir–Torre syndrome, which is known to be a phenotypical variant of hereditary nonpolyposis colorectal cancer.
Bisceglia, Michele +8 more
core +1 more source
Experimental Hematology & Oncology, 2021 The development of programmed cell death-1 inhibitor (PD-1) has shed light on the treatment of tumors with deficiencies in DNA mismatch repair system or microsatellite instability (dMMR/MSI). However, predicting the subset in this group that will benefit
Qiao-Xuan Wang +6 more
doaj +1 more source
DeepSMILE: Contrastive self-supervised pre-training benefits MSI and HRD classification directly from H&E whole-slide images in colorectal and breast cancer [PDF]
Medical Image Analysis Volume 79, July 2022, 102464, 2021 We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training and heterogeneity-aware deep Multiple Instance LEarning (DeepSMILE).
arxiv +1 more source
Does sex of the patient play a role in survival for MSI colorectal cancer? [PDF]
, 2018 Microsatellite instability (MSI) is a feature of colorectal tumors that develops as a result of inactivation of the DNA mismatch repair system. It is found in about 15% of all colorectal cancers and is an important prognostic molecular marker when ...
Alecu, Lucian +11 more
core +3 more sources
Role of microsatellite instability in colon cancer
Тазовая хирургия и онкология, 2015 Coloncancer is among leading causes of cancer morbidity and mortality both inRussiaand worldwide. Development of molecular biology lead to decoding of carcinogenesis and tumor progression mechanisms.
M. Yu. Fedyanin +2 more
doaj +1 more source
Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]
, 2004 Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G. +9 more
core +1 more source
Genome Medicine, 2021 We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas.
GiWon Shin +10 more
doaj +1 more source