Results 71 to 80 of about 91,099 (324)

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia

Genetics and Molecular Biology, 2004
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes.
Flávio Monteiro Ayres, Euza Guimarães Momotuk, Celso da Cunha Bastos, Aparecido Divino da Cruz   +3 more
doaj   +1 more source

Microsatellite instability (MSI, EMAST) in the pathogenesis of follicular lymphoma

Онкогематология, 2021
Background. Genetic instability, an important phenomenon involved in oncogenic transformation and tumor progression, is associated with the insufficiency of the multicomponent DNA repair complex, in particular, the nucleotide mismatch repair (MMR) system.
K. A. Sychevskaya, S. K. Kravchenko, N. V. Risinskaya, А. Е. Misyurina, E. E. Nikulina, F. E. Babaeva, A. B. Sudarikov   +6 more
doaj   +1 more source

Testing tumors for microsatellite instability [PDF]

European Journal of Human Genetics, 1999
The methods for determining microsatellite instability in tumors are highly heterogeneous. Recently a 5-marker panel of microsatellites was suggested for this purpose. In this review attention is drawn to the fact that microsatellite instability can be assessed by analyzing tumor DNA with a single marker, BAT-26, and that normal tissue DNA from the ...
openaire   +2 more sources

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Intrinsic structural variation of the complex microsatellite marker MYCL1 in Finnish and Somali populations and its relevance to gastrointestinal tumors

Genetics and Molecular Biology, 2006
The structurally complex MYCL1 microsatellite marker is often used to determine microsatellite instability in colorectal cancers but the allelic variation of this marker has remained largely uncharacterized in both populations and in cancers.
Hanna Vauhkonen, Antti Sajantila
doaj   +1 more source

Molecular markers as predictors of response to perioperative chemotherapy in locally advanced gastric cancer

Успехи молекулярной онкологии, 2023
Introduction. Perioperative FLOT chemotherapy has improved prognosis in patients with locally advanced resectable gastric cancer (GC). However, in 80 % of cases, the tumor is resistant to the therapy, resulting in unnecessary toxicity and delayed ...
K. A. Oganyan, A. A. Musaelyan, S. V. Lapin, T. V. Kupenskaya, A. A. Sveсhkova, M. A. Belyaev, A. A. Zakharenko, S. V. Orlov   +7 more
doaj   +1 more source

Mutational signatures in colon cancer. [PDF]

, 2019
ObjectiveRecently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often.
Marjoram, Paul, Pandey, Priyatama, Shibata, Darryl, Siegmund, Kimberly D, Yang, Zhi   +4 more
core  

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM, Armstrong, CA, Iyer, P, Jones, GD, Narayanan, D, Sandhu, J, Singh, R, Talbot, CJ, Talbot, CJ, Tufarelli, C, Tufarelli, C   +10 more
core   +2 more sources

Microsatellite instability in ovarian neoplasms [PDF]

British Journal of Cancer, 1995
Microsatellite instability has been observed in a variety of sporadic malignancies, but its existence in sporadic ovarian cancer has been the subject of conflicting reports. We have performed a polymerase chain reaction-based microsatellite analysis of DNAs extracted from the neoplastic and non-neoplastic tissues of 41 ovarian cancer patients.
King, B. L., Carcangiu, M.-L., Carter, D., Kiechle-Schwarz, Marion, Pfisterer, Jacobus, Pfleiderer, Albrecht, Kacinski, Barry   +6 more
openaire   +4 more sources