Results 81 to 90 of about 62,250 (302)

Single‐Cell Profiling Reveals Distinct Immune Hallmarks in Untreated Primary Colorectal and Liver Metastasis Cancers

Chronic Diseases and Translational Medicine, EarlyView.
Features the major cell type compositions among colon and liver metastasis. (A) The study design for single‐cell data analysis. (B) The annotated major cell types. Each type was labeled with a special color. (C) Dot plot of canonical marker genes for major cell types. (D) Bar plot of the percentage for each cell type in individuals. (E) Bar plot of the
Zhixun Zhao, Haipeng Chen, Xu Guan, Zheng Jiang, Zheng Liu, Ming Yang, Hengchang Liu, Tianli Chen, Shuangmei Zou, Yibo Gao, Xishan Wang   +10 more
wiley   +1 more source

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers

Neoplasia: An International Journal for Oncology Research, 2018
There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening.
Amy L. Cisyk, Zoann Nugent, Robert H. Wightman, Harminder Singh, Kirk J. McManus   +4 more
doaj   +1 more source

Integrating Immunotherapy Into Head and Neck Surgery: Bridging Tumor Biology to Perioperative Decision‐Making, a Review

Head &Neck, EarlyView.
ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley   +1 more source

Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Microsatellite instability in colon cancer implies favorable therapeutic outcomes after checkpoint blockade immunotherapy. However, the molecular nature of microsatellite instability is not well elucidated.Methods We examined the immune ...
Wei Wu, Qihan Fu, Lulu Liu, Yi Zheng, Hangyu Zhang, Peng Zhao, Weijia Fang, Xuanwen Bao, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Zhou Tong, Fanglong Liu   +12 more
doaj   +1 more source

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion [PDF]

, 2013
Background Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features.
Sengupta, N, Silver Andrew, Suraweera, Nirosha, Sieber, O, Sakthianandeswaren, A, Oliver Sieber, Suraweera, N, Yau, C, Jean-Baptiste Cazier, Yau, Christopher, Andrew Silver, Sieber Oliver, Lai, Cecilia, Yau Christopher, Guadalupe Polanco-Echeverry, Mouradov, Dmitri, Neel Sengupta, Sieber, Oliver, Suraweera Nirosha, Christopher Yau, Sengupta Neel, Dorudi, Sina, Feakins, R, Cazier, Jean-Baptiste, Feakins Roger, Gibbs, Peter, Sina Dorudi, Cecilia Lai, Cazier, J-B, Silver, Andrew, Peter Gibbs, Ahmed Shafi, Ahmed, Shafi, David Propper, Propper David, Thaha, M, Sakthianandeswaren Anuratha, Silver, A, Anil Ghosh, Roger Feakins, Polanco-Echeverry Guadalupe, Ghosh, Anil, Sengupta, Neel, Mohamed Thaha, Ghosh Anil, Mouradov Dmitri, Cazier Jean-Baptiste, Propper, David, Thaha Mohamed, Nirosha Suraweera, Cazier, Jean-Baptiste; id_orcid, Cazier, JB, Lai Cecilia, Dorudi, S, Anuratha Sakthianandeswaren, Ghosh, A, Shafi Ahmed, Mouradov, D, Ahmed, S, Gibbs Peter, Lai, C, Feakins, Roger, Polanco-Echeverry, G, Thaha, Mohamed, Dorudi Sina, Polanco-Echeverry, Guadalupe, Sakthianandeswaren, Anuratha, Gibbs, P, Propper, D, Dmitri Mouradov   +69 more
core   +1 more source

Microsatellite instability in colorectal cancer

British Journal of Surgery, 2006
Abstract Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although the basic mechanisms are not clear, there is increased understanding of the clinicopathological consequences of MSI.
K, Söreide, E A M, Janssen, H, Söiland, H, Körner, J P A, Baak   +4 more
openaire   +2 more sources

Microsatellite instability in ovarian neoplasms

, 1995
Summary Microsatellite instability has been observed in a variety of sporadic malignancies, but its existence in sporadic ovarian cancer has been the subject of conflicting reports.
Bl King, Kacinski, Barry, M-l Carcangiu, M Kiechle, Bm Kacinskil, BM Kacinski, King, B. L., D Carter, Pfisterer, Jacobus, Carcangiu, M.-L., Carter, D., Kiechle-Schwarz, Marion, A Pfleiderer, J Pfisterer, Pfleiderer, Albrecht   +14 more
core   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source