Results 71 to 80 of about 62,250 (302)

Differential Prognostic Impact of Prior Cholecystectomy Between Proximal and Distal Colorectal Cancer: A 12‐Year Retrospective Cohort Study of 3487 Consecutive Patients

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective cohort of 3487 patients with CRC, history of CCY was associated with significantly worse prognosis in patients with proximal CRC but not in those with distal CRC. This differential prognostic impact showed a statistically significant interaction between tumor location and history of CCY and remained robust after PSM.
Masashi Tsunematsu, Koichiro Haruki, Kazuhiro Yanamoto, Takuo Takehana, Shunta Ishizaki, Mitsuru Yanagaki, Yoshihiro Shirai, Kenei Furukawa, Shinji Onda, Toru Ikegami   +9 more
wiley   +1 more source

Testing tumors for microsatellite instability [PDF]

European Journal of Human Genetics, 1999
The methods for determining microsatellite instability in tumors are highly heterogeneous. Recently a 5-marker panel of microsatellites was suggested for this purpose. In this review attention is drawn to the fact that microsatellite instability can be assessed by analyzing tumor DNA with a single marker, BAT-26, and that normal tissue DNA from the ...
openaire   +2 more sources

Prevalence of MSI‐H/dMMR Colorectal Cancer in Japan: Data From the Clinical Study Group of the University of Osaka‐Colorectal Registry

Annals of Gastroenterological Surgery, EarlyView.
Using a multicenter Japanese colorectal cancer cohort from 25 institutions, we analyzed 1464 patients across all disease stages and tumor locations to determine the prevalence and clinicopathological features of MSI‐H/dMMR colorectal cancer. MSI‐H/dMMR tumors accounted for 9.4% of cases overall, were present in 22% of right‐sided colon cancers, and ...
Yoshihiro Morimoto, Mamoru Uemura, Yoshinori Kagawa, Hidekazu Takahashi, Masayuki Hiraki, Yozo Suzuki, Shinichi Yoshioka, Mitsuyoshi Tei, Shu Okamura, Yukako Mokutani, Atsushi Naito, Shinji Tokuyama, Takamichi Komori, Akinobu Yasuyama, Genta Sawada, Yujiro Fujie, Shinya Yamashita, Naotsugu Haraguchi, Yusuke Matsuura, Chu Matsuda, Yoshinao Chinen, Tatsushi Shingai, Katsuki Danno, Nobuo Tanaka, Kazuya Sakata, Kohei Murata, Yuichiro Doki, Hidetoshi Eguchi   +27 more
wiley   +1 more source

Medullary colon carcinoma with microsatellite instability: case report

Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern.
Mariana Macambira Noronha, Leonardo Saraiva Pontes, Gabriel Sampaio Feitosa, Mayra Wilma Martins Cardoso Soares, Igor Santos Costa, José Walter Feitosa Gomes, Elam Vasconcelos de Aquino   +6 more
core   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts

Virology Journal, 2012
Background Marek’s disease virus (MDV), an oncogenic α-herpes virus, causes a devastating disease in chickens characterized by development of lymphoblastoid tumors in multiple organs.
Zhou Zhenlei, Yao Dawei, Qiu Yan, Yang Deji   +3 more
doaj   +1 more source

LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. [PDF]

PLoS ONE, 2007
Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently.
Marcos R H Estécio, Vazganush Gharibyan, Lanlan Shen, Ashraf E K Ibrahim, Ketan Doshi, Rong He, Jaroslav Jelinek, Allen S Yang, Pearlly S Yan, Tim H-M Huang, Eloiza H Tajara, Jean-Pierre J Issa   +11 more
doaj   +1 more source

Microsatellite instability and pathological aspects of breast cancer

, 1995
Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non ...
Contegiacomo A, Palmirotta R, Figliolini M, Delrio P, Bianco AR, Mastranzo P, Petrella G, MARIANI COSTANTINI, Renato, De Marchis L, CAMA, Alessandro, Pizzi C, Frati L   +11 more
core   +2 more sources

Znaczenie mechanizmu naprawy DNA błędnie sparowanych zasad azotowych (MMR) w raku piersi

Menopause Review, 2010
Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers.
Hanna Romanowicz, Beata Smolarz, Tomasz Fiks, Andrzej Kulig, Ireneusz Połać, Anna Sobczuk, Tomasz Pertyński   +6 more
doaj  

Identification of a novel deletion mutant strain in Saccharomyces cerevisiae that results in a microsatellite instability phenotype [PDF]

BioDiscovery, 2012
The DNA mismatch repair (MMR) pathway corrects specific types of DNA replication errors that affect microsatellites and thus is critical for maintaining genomic integrity.
Hanlee P. Ji, Shannon Morales, Katrina Welch, Cam Yuen, Kyle Farnam, James M Ford   +5 more
doaj   +3 more sources