Results 201 to 210 of about 55,724 (327)

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Additional file 2 of Recent amplification of microsatellite-associated miniature inverted-repeat transposable elements in the pineapple genome

, 2021
Lian-Yu Lin, Anupma Sharma, Qingyi Yu
openalex   +2 more sources

Evaluation of Multiple Tissue Levels Frequently Upstages Patients With Clinically Localized Thin Primary Cutaneous Melanoma

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Breslow thickness (BT), ulceration, and microsatellitosis are critical prognostic parameters for cutaneous melanoma staging. These parameters can vary depending on the number of tissue levels examined from individual paraffin blocks.
Louise A. Jackett, James P. Gullifer, Richard A. Scolyer   +2 more
wiley   +1 more source

Association Analysis of a Microsatellite Repeat in the TRIB1 Gene With Prostate Cancer Risk, Aggressiveness and Survival [PDF]

, 2018
Leire Moya, John Lai, Andrea Hoffman, Srilakshmi Srinivasan, Janaththani Panchadsaram, Suzanne K. Chambers, Judith A. Clements, Jyotsna Batra   +7 more
openalex   +1 more source

Additional file 4 of Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

, 2021
Gi Won Shin, Stephanie Greer, Erik Hopmans, Susan M. Grimes, HoJoon Lee, Lan Zhao, Laura Miotke, Carlos J. Suarez, Alison Almeda, Sigurdís Haraldsdóttir, Hanlee P. Ji   +10 more
openalex   +2 more sources

ATAD3 duplications bridge mitochondrial diseases and Aicardi–Goutières syndrome

Developmental Medicine &Child Neurology, EarlyView.
ATAD3 locus duplications cause a severe neonatal mitochondrial disorder with neuroimaging features resembling interferonopathies, and suggest a mitochondrial nucleic acid‐triggered interferon response. Abstract A recurrent 68‐kb heterozygous duplication of the ATAD3 locus has been implicated in a mitochondrial disorder characterized by prenatal or ...
Pauline Planté‐Bordeneuve, Claire‐Marine Bérat, Sylvain Hanein, Cyril Gitiaux, ATAD3 Study Group, Julie Steffann, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia, Brian Sperelakis‐Beedham, Zahra Assouline, Marie‐Thérèse Abi‐Warde, Rukhshona Abdullazoda, Agnès Guichet, Céline Bris, Aurélien Caux, Marlène Rio, Jérémy Bertrand, Pauline Gaignard, Alice Lepelley, Arnold Munnich, Manuel Schiff, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia   +26 more
wiley   +1 more source

Accurate measurement of microsatellite length by disrupting its tandem repeat structure

, 2022
Zihua Wang, Andrea B. Moffitt, Peter Andrews, Michael Wigler, Dan Levy   +4 more
openalex   +2 more sources

Circulating hsa‐miR‐29c‐3p and VEGF‐A levels predict the response to FOLFIRI plus aflibercept in elderly metastatic colorectal cancer patients

European Journal of Clinical Investigation, EarlyView.
Metastatic colorectal cancer (mCRC) patients who progress on oxaliplatin‐based chemotherapy benefit from second‐line treatment with FOLFIRI plus aflibercept. However, the absence of validated biomarkers for antiangiogenic therapies remains a challenge. Circulating levels of VEGF‐A and 13 miRNAs were analysed in 154 elderly mCRC patients.
Marta Toledano‐Fonseca, María Teresa Cano‐Osuna, Elena Élez, Javier Soto‐Alsar, David Páez, Ana Fernández‐Montes, Begoña Graña, Antonieta Salud, Alfonso Yubero, Ismael Macías, Guillermo Quintero, Carlos López‐López, Teresa Fernández‐Rodríguez, María Victoria García‐Ortiz, Javier Sastre, Pilar García‐Alfonso, Antonio Rodríguez‐Ariza, Enrique Aranda, on behalf of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)   +18 more
wiley   +1 more source

Supplementary Legends for Figures 1-5, Table 1 from An A13 Repeat within the 3′-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression

, 2023
Ziqiang Yuan, Joongho Shin, Andrew Wilson, Sanjay Goel, Yi‐He Ling, Naseem Ahmed, Higinio Dopeso, Minaxi Jhawer, Shannon Nasser, Cristina Montagna, Kenneth Fordyce, Leonard H. Augenlicht, Lauri A. Aaltonen, Diego Arango, Thomas K. Weber, John M. Mariadason   +15 more
openalex   +2 more sources

Invasive insect genetics: Start codon targeted (SCoT) markers provide superior data to describe genetic diversity of brown marmorated stink bug, Halyomorpha halys, in a newly colonized region

Entomologia Experimentalis et Applicata, EarlyView.
In this study, we assessed the genetic diversity of Halyomorpha halys, an invasive agricultural pest, in Türkiye using start codon targeted (SCoT) markers and mitochondrial cytochrome c oxidase subunit I (COI) sequences. SCoT markers revealed high polymorphism (91.4%) and six genetic clusters among 71 specimens from 12 provinces, with Trabzon showing ...
Ismail Oguz Ozdemir, Irem Turan, Mehtap Alkan, Celal Tuncer, Vaughn Walton, Göksel Özer   +5 more
wiley   +1 more source