Results 221 to 230 of about 31,304 (305)

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Integrating morphology, nuclear SSR, and chloroplast genomes to investigate hybrid origin and species delimitation in the Lycium barbarum L. and its varieties in China. [PDF]

BMC Ecol Evol
Zhang L, Zhao J, Zhang C, Liao X, Zheng G, Wei Y.   +5 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Birth-Death Dynamics of Microsatellites: Mechanistic Insights from Orthologous Loci in Felidae. [PDF]

Genes (Basel)
Zhang W, Zhang M, Liu H.
europepmc   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Genetic diversity and breeding efficiency of a salt-tolerant strain of largemouth bass (Micropterus salmoides) revealed by microsatellite analysis and phenotypic evaluations. [PDF]

Sci Rep
Tian J, Liu Y, Lei C, Cheng L, Yang B, Du J, Zhu T, Li S, Song H.   +8 more
europepmc   +1 more source

Genomic Variation and Population Structure of Portuguese Native Dog Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The presence of dogs in Portugal is confirmed by zooarchaeological evidence dating to at least 7600 years ago. The 11 native dog breeds that exist in this territory are therefore the end‐product of a complex evolutionary process. This study characterises the genomic diversity and population structure of 10 native breeds based on whole‐genome ...
Ludmilla Blaschikoff, Octávio Serra, Fernanda Simões, Catarina Ginja, Ana Elisabete Pires   +4 more
wiley   +1 more source

Microsatellite Markers Developed Based on Transcriptomic Data Reveal the Genetic Diversity and Population Genetic Structure of <i>Angulyagra polyzonata</i> in Guangxi, China. [PDF]

Biology (Basel)
Zhang S, Wang D, Zhou K, Lin Y, Chen Z, Qin J, Du X, Long L, Zhang C, Pan X, Li W.   +10 more
europepmc   +1 more source

A Breed‐Specific SNP Panel With Higher Theoretical Exclusion Power and Practical Equivalence to International Standards for Parentage Testing in Pura Raza Española Horses

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Accurate parentage assignment is essential for managing livestock breeding and genetic improvement. This study evaluated a breed‐specific SNP panel (375 SNPs) for the Pura Raza Española (PRE) horse, comparing its performance against the traditional STR reference panel (18 microsatellite) and the international ISAG SNP core panel (378 SNPs ...
Nora Laseca, Antonio Molina, Tristan Marshall, Ismael González, Julia Poyato‐Bonilla, Mercedes Valera   +5 more
wiley   +1 more source

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer. [PDF]

Curr Oncol
Yilmaz A, Frankel WL, Swanson BJ, Miller K, Bacher J, Bigley C, Nelsen L, Kalady MF, Coleman JF, Pearlman R, Hampel H.   +10 more
europepmc   +1 more source