Results 211 to 220 of about 48,754 (308)

UBE2C‐Mediated CD147‐CTLA‐4 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer

Cancer Science, EarlyView.
UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong, Ting Hong, Xinyu Liu, Peixiu Yao, Weiqiang Lin, Guoyuan Liu, Huihong Guan, Yonghai Zhang   +7 more
wiley   +1 more source

Current Status of the Diagnosis and Treatment of Mismatch Repair Deficient Colorectal Cancer. [PDF]

Biomedicines
Bastin DJ, Djedovic V, Hyde A, Goodwin RA, Asmis TR, Vickers MM.   +5 more
europepmc   +1 more source

Budding speciation, mitochondrial capture and introgression between surface and cave lineages in the Asellus aquaticus species complex

Cladistics, EarlyView.
Abstract Replicated pairs of ancestral and evolutionarily derived populations provide opportunities to test hypotheses about the deterministic laws of evolution. The Asellus aquaticus species complex is an invertebrate model system with several independent surface‐to‐cave transitions and a complicated and unresolved evolutionary history.
Peter Trontelj, Valerija Zakšek, Anja Palandačić, Hans Recknagel   +3 more
wiley   +1 more source

Satellite DNA Genomics: The Ongoing Story. [PDF]

Int J Mol Sci
Garrido-Ramos MA, Plohl M, Šatović-Vukšić E.   +2 more
europepmc   +1 more source

Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropods

Conservation Biology, EarlyView.
Abstract Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices.
E. Portanier, A. Tran Lu Y, F. Pradillon, C. Daguin‐Thiébaut, S. Ruault, P. Collins, E. Omnes, S. Fuchs, J. Carlsson, D. Jollivet, M. Matabos   +10 more
wiley   +1 more source

Deep Dermal and Subcutaneous Deposits in Thin Melanoma: A Cautionary Tale. [PDF]

J Cutan Pathol
Cheng A, Gruchy J, Burns A, Langley R, Williams J, DeCoste R.   +5 more
europepmc   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Past Colony Connectivity of a Declining Seabird Derived From Host-Parasite Genetic Data. [PDF]

Ecol Evol
Cargill CP, McCoy KD, Scott BE, Masden EA, Miller J, Ruffino L, Payo-Payo A.   +6 more
europepmc   +1 more source