Acta Ophthalmologica, EarlyView.Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer +5 more
wiley +1 more source
Chromosome 1p and 6q Loss of Heterozygosity in Meningioma: A Comprehensive Analysis of the Two Chromatin Remodeling Complex Subunits ARID1A and ARID1B. [PDF]
Cancers (Basel)Hinsberger M +6 more
europepmc +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
The whole genome analysis of four Orf virus strains from Europe and South America. [PDF]
Virus EvolCacciabue M +8 more
europepmc +1 more source
Cancer Science, EarlyView.Whole‐genome sequencing of ~50,000 individuals from the Tohoku Medical Megabank (TMM) cohort defines the prevalence, mutational landscape, and age dependency of clonal hematopoiesis in the Japanese population, demonstrating overall concordance with clonal hematopoiesis detected in cancer patients.
SungGi Chi +12 more
wiley +1 more source
Birth-Death Dynamics of Microsatellites: Mechanistic Insights from Orthologous Loci in Felidae. [PDF]
Genes (Basel)Zhang W, Zhang M, Liu H.
europepmc +1 more source
Cancer Science, EarlyView.YPEL3 functions as a tumor suppressor in HNSCC by inhibiting tumor progression and promoting apoptosis. Mechanistically, it enhances epithelial–immune crosstalk through the CREB1‐mediated CXCL16–CXCR6 axis, facilitating CD8+ T‐cell infiltration and highlighting its potential as a prognostic biomarker and immunotherapy target.
Yalun Li +7 more
wiley +1 more source
Fine Characterization of the Contact Zones of <i>Mazzaella laminarioides</i> in the Southeastern Pacific Using Mitochondrial and Nuclear Markers. [PDF]
Ecol EvolQuesada S +4 more
europepmc +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, EarlyView.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
Transcriptomic analysis of long non coding RNAs and their association with TET family genes in Sus scrofa embryo. [PDF]
Sci RepJali I, Sharma S.
europepmc +1 more source