Results 181 to 190 of about 31,010 (266)

Past Colony Connectivity of a Declining Seabird Derived From Host-Parasite Genetic Data. [PDF]

Ecol Evol
Cargill CP, McCoy KD, Scott BE, Masden EA, Miller J, Ruffino L, Payo-Payo A.   +6 more
europepmc   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Genetic structure of sugar kelp in the St. Lawrence Estuary and Gulf (Québec, Canada). [PDF]

J Phycol
Treillefort M, Le Cam S, Valero M, Mauger S, Ruggeri P, Salvo F, Gendron-Lemieux I, Provencher T, Belley R, Dufresne F.   +9 more
europepmc   +1 more source

UBE2C‐Mediated CD147‐CTLA‐4 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer

Cancer Science, EarlyView.
UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong, Ting Hong, Xinyu Liu, Peixiu Yao, Weiqiang Lin, Guoyuan Liu, Huihong Guan, Yonghai Zhang   +7 more
wiley   +1 more source

Genome-Wide Microsatellite Characterization and Molecular Marker Development of Himalayan Griffon (<i>Gyps himalayensis</i>). [PDF]

Animals (Basel)
Guo W, Ke D, Wang C, Fan H.
europepmc   +1 more source

Phase II Trial of Nivolumab in Advanced Solid Tumors Based on Genomic Profiling: BELIEVE Trial (NCCH1901) Subcohort

Cancer Science, EarlyView.
Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai, Kuniko Sunami, Tatsunori Shimoi, Satoshi Nishiwaki, Ichiro Kinoshita, Tetsuhiro Yoshinami, Chigusa Morizane, Yusuke Sato, Toshio Kubo, Mamoru Ito, Hiroshi Nishihara, Toru Mukohara, Hidekazu Shirota, Ryo Ko, Taro Shibata, Manabu Muto, Noboru Yamamoto   +16 more
wiley   +1 more source

Development of Microsatellite Markers for Ex Situ Management of the Harpy Eagle Using Next Generation Sequencing. [PDF]

Zoo Biol
Kaizer M, Bittencourt PS, Polo ÉM, Sanaiotti TM, Farias IP, von Fersen L, Hrbek T, Banhos A.   +7 more
europepmc   +1 more source

The Evolving Landscape of Rectal Cancer Management—A Case for Centralisation?

ANZ Journal of Surgery, EarlyView.
Rathin Gosavi, Alexander Heriot, Satish K. Warrier   +2 more
wiley   +1 more source

Immunological Heterogeneity in Gastric Cancer: Context‐Dependent Role of CD8+ T Cells

Cancer Science, EarlyView.
CD8+ T cell infiltration in gastric cancer shows subtype‐dependent prognostic and predictive significance across TCGA molecular subtypes. Its clinical value is context‐dependent and requires integrated immune profiling to guide modern chemoimmunotherapy strategies.
Xiaofei Sun, Zihao Yang, Hongtao Qu, Jinhui Wu   +3 more
wiley   +1 more source

The Application of Microsatellite Markers as Molecular Tools for Studying Genomic Variability in Vertebrate Populations. [PDF]

Curr Issues Mol Biol
Kulibaba RO, Srikulnath K, Singchat W, Liashenko YV, Griffin DK, Romanov MN.   +5 more
europepmc   +1 more source