Results 111 to 120 of about 1,009,075 (346)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An attempt to unify some population growth models from first principles

Revista Brasileira de Ensino de Física
In this work, some phenomenological growth models based only on the population information (macroscopic level) are deduced in an intuitive way. These models, for instance Verhulst, Gompertz and Bertalanffy-Richards models, are introduced in such a way ...
Fabiano L. Ribeiro
doaj   +1 more source

Global phenomenological and microscopic optical model potentials for alpha

EPJ Web of Conferences, 2017
The global phenomenological and microscopic optical model potentials for alpha with the incident energy up to 400 MeV are obtained. The global phenomenological optical model potential is extracted by simultaneously fitting the experimental data of total ...
Guo Hairui, Su Xinwu, Liang Haiying, Xu Yongli, Han Yinlu, Shen Qingbiao   +5 more
doaj   +1 more source

Macroscopic-Microscopic Mass Models

, 1995
10 pages. LaTeX. Presented at International Conference on Exotic Nuclei and Atomic Masses (ENAM 95), Arles, France, June 19-23, 1995. To be published in conference proceedings by Les Editions Frontieres, Gif sur Yvette, France. Seven figures not included here. PostScript version with figures available at http://t2.lanl.gov/pub/publications/publications.
Nix, J. R., Moller, P.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Damage analysis of solid propellants with default defects based on macro-microscopic approach

Materials & Design
Solid Rocket Motors (SRMs) rely on solid propellants, directly impacting the energy capacity of launch vehicles. High energy density material (HEDM) propellant exhibits superior energy density owing to the incorporation of a substantial quantity of ...
Kaining Zhang, Zhelin Dong, Chongpu Zhai, Chunguang Wang, Qun Li, Xiaoying Wang   +5 more
doaj   +1 more source

Appearance of Hagedorn limiting temperature in microscopic model calculations

EPJ Web of Conferences, 2016
One of important consequences of Hagedorn statistical bootstrap model is the prediction of limiting temperature Tcrit for hadron systems colloquially known as Hagedorn temperature.
Zabrodin E., Bravina L., Bleicher M., Stöcker H.   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Large-scale microscopic traffic simulation based on license plate recognition data and OpenStreetMap

Journal of Highway and Transportation Research and Development
Microscopic traffic simulation can provide scientific support for traffic design, traffic planning, traffic monitoring, and traffic demand management, and how to construct accurate and efficient microscopic traffic simulation is an important research ...
Wenbin Yao, Youwei Hu, Yexing Yin, Jia Guo, Congcong Bai, Zuoming Zhang, Sheng Jin   +6 more
doaj   +1 more source

Effective large-scale model of boson gas from microscopic theory

Nuclear Physics B, 2019
An effective large-scale model of interacting boson gas at low temperatures is constructed from first principles. The starting point is the generating function of time-dependent Green functions at finite temperature.
Juha Honkonen, M.V. Komarova, Yu.G. Molotkov, M.Yu. Nalimov   +3 more
doaj   +1 more source