Results 121 to 130 of about 1,011,329 (344)
From Microscopic Droplets to Macroscopic Crowds: Crossing the Scales in Models of Short‐Range Respiratory Disease Transmission, with Application to COVID‐19 [PDF]
, 2023 Simon Mendez +2 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A microscopic normal matrix model for (A)dS 2
Journal of High Energy PhysicsWe describe the duality between the gravitating c = 1 (compact) Sine-Gordon model and a normal matrix model. From a two-dimensional quantum gravity perspective and due to the periodic nature of the potential, this model admits both anti-de Sitter and de ...
Panos Betzios
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Appearance of Hagedorn limiting temperature in microscopic model calculations
EPJ Web of Conferences, 2016 One of important consequences of Hagedorn statistical bootstrap model is the prediction of limiting temperature Tcrit for hadron systems colloquially known as Hagedorn temperature.
Zabrodin E. +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Global phenomenological and microscopic optical model potentials for alpha
EPJ Web of Conferences, 2017 The global phenomenological and microscopic optical model potentials for alpha with the incident energy up to 400 MeV are obtained. The global phenomenological optical model potential is extracted by simultaneously fitting the experimental data of total ...
Guo Hairui +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A constitutive law for cross-linked actin networks by homogenization techniques
, 2010 Inspired by experiments on the actin driven propulsion of micrometer sized beads we develop and study a minimal mechanical model of a two-dimensional network of stiff elastic filaments grown from the surface of a cylinder.
Caillerie, Denis +4 more
core +1 more source