Results 111 to 120 of about 1,011,329 (344)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

An attempt to unify some population growth models from first principles

Revista Brasileira de Ensino de Física
In this work, some phenomenological growth models based only on the population information (macroscopic level) are deduced in an intuitive way. These models, for instance Verhulst, Gompertz and Bertalanffy-Richards models, are introduced in such a way ...
Fabiano L. Ribeiro
doaj   +1 more source

MP80-17 MODELING THE RISK OF RADIATION FROM CT UROGRAPHY IN THE EVALUATION OF ASYMPTOMATIC MICROSCOPIC HEMATURIA [PDF]

, 2018
Todd Yecies, Jathin Bandari, Benjamin Davies, Bruce L. Jacobs   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Damage analysis of solid propellants with default defects based on macro-microscopic approach

Materials & Design
Solid Rocket Motors (SRMs) rely on solid propellants, directly impacting the energy capacity of launch vehicles. High energy density material (HEDM) propellant exhibits superior energy density owing to the incorporation of a substantial quantity of ...
Kaining Zhang, Zhelin Dong, Chongpu Zhai, Chunguang Wang, Qun Li, Xiaoying Wang   +5 more
doaj   +1 more source

Microscopic modelling of doped manganites [PDF]

, 2004
Alexander Weiße, Holger Fehske
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Formation and decay of resonance state in 9Be and 9B nuclei. Microscopic three-cluster model investigations

Physical Sciences and Technology, 2017
We study nature of the low-lying resonance states in mirror nuclei 9Be and 9B. Investigations are performed within a three-cluster model. The model make uses of the hyperspherical harmonics, which provide convenient description of three-cluster continuum.
V. S. Vasilevsky, K. Kato, N. Zh. Takibayev   +2 more
doaj  

Large-scale microscopic traffic simulation based on license plate recognition data and OpenStreetMap

Journal of Highway and Transportation Research and Development
Microscopic traffic simulation can provide scientific support for traffic design, traffic planning, traffic monitoring, and traffic demand management, and how to construct accurate and efficient microscopic traffic simulation is an important research ...
Wenbin Yao, Youwei Hu, Yexing Yin, Jia Guo, Congcong Bai, Zuoming Zhang, Sheng Jin   +6 more
doaj   +1 more source

Two models based on local microscopic relaxations to explain long-term basic creep of concrete [PDF]

, 2018
Matthieu Vandamme
openalex   +1 more source