Results 61 to 70 of about 331,732 (145)

Pulmonary manifestations of granulomatosis with polyangiitis and microscopic polyangiitis

Seminars in Arthritis and Rheumatism
ANCA-associated vasculitis (AAV) can have several pulmonary manifestations. There is limited knowledge of the epidemiology and complications of pulmonary manifestations in AAV, despite their association with increased mortality and reduced health-related quality of life.This study retrospectively analyzed a large, multicentre longitudinal cohort of ...
Mats Junek, Seungwon Choi, Stephanie Garner, Saara Rawn, Gerard Cox, Nader Khalidi, David Cuthbertson, Curry L Koening, Carol A. Langford, Carol A. McAlear, Paul A. Monach, Larry W. Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Kenneth J. Warrington, Peter A. Merkel   +16 more
openaire   +2 more sources

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Microscopic Polyangiitis Initially Presumed to Be Endocarditis

, 2020
The antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAVs), which include fever of unknown origin (FUO), are rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCAs.
Shunsuke Hino, Yosuke Iijima, Norio Horie, Takahiro Kaneko   +3 more
core   +1 more source

Cochlear Implantation in Autoimmune Inner‐Ear Disease: Outcome and Patient‐Reported Benefit

The Laryngoscope, Volume 136, Issue 9, Page 3980-3989, September 2026.
This study demonstrates that patients with secondary autoimmune inner‐ear disease (AIED) achieve significant improvements in speech perception and quality of life following cochlear implantation. Although AIED patients may show slightly lower performance in noisy environments compared to controls, their subjective hearing benefit converges with matched
Merete Hartmann, David Oestreicher, Marc Albert Hüser, Dirk Beutner, Christian Wrobel   +4 more
wiley   +1 more source

Hypocomplementemia is associated with worse renal survival in ANCA-positive granulomatosis with polyangiitis and microscopic polyangiitis - Fig 1

, 2018
Kaplan-Meier estimate of overall (A), renal (B) and relapse-free (C) survival rates in patients with granulomatosis with polyangiitis or microscopic polyangiitis, according to low or normal plasma complement levels (absolute values) performed before ...
Thierry Lobbedez (2579155), Kathy Khoy (5067125), Nicolas Martin Silva (2579191), Samuel Deshayes (3257217), Achille Aouba (5067131), Delphine Mariotte (5067128)   +5 more
core   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, Volume 81, Issue 9, Page 3171-3184, September 2026.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Microscopic polyangiitis, an onset with diffuse alveolar hemorrhage [PDF]

Introduction: antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a group of complex chronic diseases that cause morbidity, systemic organ damage, therapeutic overload, and risk of relapse. Microscopic polyangiitis (MPA) primarily affects
Zambrano Gilces, Isis Micaela, Navas Vargas, Evelyn Patricia, Cortés Morales, Mayra Carolina, Magallanes Bajaña, Angelo Andy, Loaiza Correa, Karen Patricia, Cabezas Euvin, Daniel   +5 more
core   +2 more sources

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, Volume 81, Issue 8, Page 2775-2791, August 2026.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Interstitial lung disease in microscopic polyangiitis and granulomatosis with polyangiitis: demographic, clinical, serological and radiological features of an Italian cohort from the Italian Society for Rheumatology

, 2022
Interstitial lung disease (ILD) has been described as a possible pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV), mainly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Aim of
Felicetti, Mara, De Vita, Salvatore, Cantini, Fabrizio, Dallagiacoma, Gloria, Monti, Sara, Kaleci, Shaniko, Sebastiani, Marco, Study Group of the Italian Society for Rheumatology (SIR), Izzo, Raffaella, Giollo, Alessandro, Cassone, Giulia, Conticini, Edoardo, Padoan, Roberto, Caporali, Roberto, Rossini, Maurizio, Dagna, Lorenzo, Montecucco, Carlomaurizio, Muratore, Francesco, Quartuccio, Luca, Manfredi, Andreina, Govoni, Marcello, Nannini, Carlotta, Berti, Alvise, Frediani, Bruno, Cariddi, Adriana, Argolini, Lorenza Maria, Emmi, Giacomo, Bettio, Silvano, Salvarani, Carlo, Dejaco, Christian   +29 more
core   +1 more source

ANCA-associated vasculitis in childhood: recent advances

Italian Journal of Pediatrics, 2017
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are rare systemic diseases that usually occur in adulthood. They comprise granulomatosis with polyangiitis (GPA, Wegener’s), microscopic polyangiitis (MPA) and eosinophilic ...
Marta Calatroni, Elena Oliva, Davide Gianfreda, Gina Gregorini, Marco Allinovi, Giuseppe A. Ramirez, Enrica P. Bozzolo, Sara Monti, Claudia Bracaglia, Giulia Marucci, Monica Bodria, Renato A. Sinico, Federico Pieruzzi, Gabriella Moroni, Serena Pastore, Giacomo Emmi, Pasquale Esposito, Mariagrazia Catanoso, Giancarlo Barbano, Alice Bonanni, Augusto Vaglio   +20 more
doaj   +1 more source