Results 41 to 50 of about 3,224,759 (251)

Microscopic simulation of membrane molecule diffusion on corralled membrane surfaces [PDF]

, 2008
The current understanding of how receptors diffuse and cluster in the plasma membrane is limited. Data from single-particle tracking and laser tweezer experiments have suggested that membrane molecule diffusion is affected by the presence of barriers ...
Edwards, Jeremy S., Vlachos, Dionisios G., Tribe, Roger, Plechac, Petr, Niehaus, Anne Marie S.   +4 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Performance of car following behaviour in microscopic traffic flow models [PDF]

, 2004
Microscopic simulation models are becoming increasingly important tools in modelling transport systems. They are applied in simulation programs for transport planning, traffic forecasting and advanced vehicle control and safety systems (AVCSS).
Brockfeld, Elmar, Wagner, Peter, Kelpin, Rene   +2 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Calibration and Validation of Microscopic Traffic Flow Models [PDF]

, 2004
Microscopic simulation models are becoming increasingly important tools in modeling transport systems. There are a large number of available models used in many countries.
Brockfeld, Elmar, Kühne, Reinhart, Wagner, Peter   +2 more
core  

Environmental Impact from Vehicle–Pedestrian Interactions at Unsignalized Mid-Block Raised Crosswalks: A Microscopic Perspective

Eng
Unsignalized mid-block raised crosswalks are widely used to improve pedestrian safety by prompting drivers to yield. However, on arterial roads they conflict with vehicular continuity, while their environmental effects remain insufficiently understood ...
José Roberto Pérez-Cruz, Antonio Hurtado-Beltran, Noureddine Lakouari, Rachid Marzoug   +3 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Event traffic forecast for metropolitan areas based on microscopic simulation [PDF]

, 2008
It is shown that a traditional travel demand forecast combined with a simulationbased approach can serve as a short-term forecast for the traffic situation.
Elmar Brockfeld, Michael Behrisch, Daniel Krajzewicz, Brockfeld, Elmar, Michael Bonert, Wagner, Peter, Bonert, Michael, Peter Wagner, Behrisch, Michael, Krajzewicz, Daniel   +9 more
core  

Large-scale microscopic traffic simulation based on license plate recognition data and OpenStreetMap

Journal of Highway and Transportation Research and Development
Microscopic traffic simulation can provide scientific support for traffic design, traffic planning, traffic monitoring, and traffic demand management, and how to construct accurate and efficient microscopic traffic simulation is an important research ...
Wenbin Yao, Youwei Hu, Yexing Yin, Jia Guo, Congcong Bai, Zuoming Zhang, Sheng Jin   +6 more
doaj   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source