Results 21 to 30 of about 3,224,759 (251)

Research Progress on the Microscopic Mechanism of Alloying Elements Regulating Hydrogen Permeation Behavior

Liaoning Shiyou Huagong Daxue xuebao
Hydrogen permeation is a pivotal factor inducing hydrogen embrittlement (HE) in pipeline steels. Alloying presents an effective strategy for enhancing both the mechanical properties and HE resistance of these steels.
Mingyue WANG, Liangxue CAI, Guangli XU
doaj   +1 more source

Sensitivity Analysis for Microscopic Crowd Simulation

Algorithms, 2020
Microscopic crowd simulation can help to enhance the safety of pedestrians in situations that range from museum visits to music festivals. To obtain a useful prediction, the input parameters must be chosen carefully. In many cases, a lack of knowledge or
Marion Gödel, Rainer Fischer, Gerta Köster   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Calibration of microscopic traffic simulation models: Methods and application

, 2007
A mathematical framework and a solution approach are presented for the simultaneous calibration of the demand and supply parameters and inputs to microscopic traffic simulation models as well as a large-scale application emphasizing practical issues ...
Wen, Yang,, Wen, Y, Balakrishna, R.,, Koutsopoulos, Haris N.,, Antoniou, C, Antoniou, C.,, Balakrishna, R, Ben-Akiva, M.,, Ben-Akiva, M, Koutsopoulos, HN   +9 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Review of Data Collection Methods for Microscopic Traffic Simulation [PDF]

, 2004
Research into developing more reliable microscopic traffic simulation models is seriously hampered by the availability of suitable microscopic data for calibration and validation purposes.
Wagner, Peter, Hidas, Peter
core  

An examination of the microscopic simulation models to identify traffic safety indicators [PDF]

, 2011
Evaluating the safety of different traffic facilities is a complex and crucial task. Microscopic simulation models have been widely used for traffic management but have been largely neglected in traffic safety studies. Micro simulation to study safety is
Kaveh Bevrani, Chung, Edward, Bevrani, Kaveh, Edward Chung   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Passenger evacuation during subway escalator malfunction under mass passenger flow

Shenzhen Daxue xuebao. Ligong ban
Subway stations are characterized by mass passenger flow, complex evacuation routes and limited underground space. Failure to evacuate passengers in a timely manner during emergency situations may lead to panic, serious safety accidents and property loss.
LI Weiwei, LOU Xiaolei, YANG Wenjie, HU Mingwei, DENG Xuan   +4 more
doaj   +1 more source