Results 31 to 40 of about 3,224,759 (251)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The Econometric Analysis of Microscopic Simulation Models [PDF]
Microscopic simulation models are often evaluated based on visual inspection of the results.This paper presents formal econometric techniques to compare microscopic simulation (MS) models with real-life data.A related result is a methodology to compare ...
Melenberg, B., Li, Y., Donkers, A.C.D.
core +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
, 2022 S.444-448This paper compares a microscopic discrete-event simulation model and a mesoscopic discrete-rate simulation model to support the planning of a production line in the automotive industry in terms of simulation results and modeling and simulation ...
Reggelin, T., Gleye, F., Lang, S.
core +1 more source
ASM Science Journal, 2022 The activity of pedestrian movement can be predicted by a pedestrian model. Pedestrian model would assign pedestrian lane characteristic, especially for capacity.
Muchammad Zaenal Muttaqin, ahmad Munawar
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Adding intermodality to the microscopic simulation package SUMO [PDF]
, 2010 It is shown how the traffc simulation SUMO which traditionally focused on individual road traffc could be extended to serve the purpose of a general traffic simulation (including transport of individual persons) while retaining most of in- and output
Erdmann, Jakob +2 more
core
Study of pedestrian-vehicle interaction behaviour by microscopic simulation modelling
, 2012 Walking is healthy, environmentally beneficial and sustainable to human society. Travellers increasingly are being encouraged to walk more. However, pedestrians’ interaction with motorised vehicles is a major constraint to their movement. Many innovative
Wang, Tianjiao
core +1 more source
PERFORMANCE EVALUATION OF ROUNDABOUTS USING A MICROSCOPIC SIMULATION MODEL [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2019 Contemporary planning of the road network in cities assumes the use of transport models. The microscopic model allows provision of information and decision-making regarding, for example, emissions, traffic organisation, geometrics of the intersection and
Marcin Jacek KLOS, Aleksander SOBOTA
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source