Advanced Science, EarlyView.A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
A microscopic traffic characterization considering the impact of density on carbon emissions from CAVs. [PDF]
Sci RepKhan ZH +4 more
europepmc +1 more source
Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning
Advanced Science, EarlyView.ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen +6 more
wiley +1 more source
Two-dimensional ETTC-labeled longitudinal and lateral conflicts for interpretable real-time crash risk prediction in freeway interchange diverging areas. [PDF]
PLoS OneTang F, Wu R, Liu Z, Zhong S.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Research on optimization of train routing problem for railway hubs considering passenger demand. [PDF]
PLoS OneWang Y.
europepmc +1 more source
Evaluating the environmental impacts of bus priority strategies at traffic signals
, 2011 Buses, the main form of public transport in many urban areas, are considered as an efficient and environmentally friendly transport mode because of their high passenger capacity.
Zhang, Jing
core
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
An analysis of traffic-flow stability in a microscopic heterogeneous network
, 2013 Microscopic traffic-flow networks are typicallydesigned to simulate vehicle acceleration behaviourusing a single mathematical model. The concept ofstability is a major objective of microscopic drivermodels for traffic simulations.
Peursum, Sarah +2 more
core
Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, EarlyView.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source