Results 121 to 130 of about 13,370 (299)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

A General Microscopic Traffic Model Yielding Dissipative Shocks

, 2017
We consider a general microscopic traffic model with a delay. An algebraic traffic function reduces the equation to the Aw-Rascle microscopic model while a sigmoid function gives the standard “follow the leader”.
Mads Peter Sørensen, Peter Leth Christiansen, Caputo, Jean Guy, Christiansen, Peter Leth, Sørensen, Mads, Rasmussen, Jens Juul, Yuri Borissovich Gaididei, Gaididei, Yuri Borisovich, Jean-Guy Caputo, Jens Juul Rasmussen   +9 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Applying Situated Agents to Microscopic Traffic Modelling

, 2009
Trading off between realism and too much abstraction is an important issue to address in microscopic traffic simulation. In this chapter the authors bring this discussion forward and propose a multi-agent model of the traffic domain where integration is ...
Paulo A. F. Ferreira, Rosaldo J. F. Rossetti, Edgar F. Esteves, Eugénio C. Oliveira   +3 more
core  

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Validation of Microscopic Traffic Models Based on GPS Precise Measurement of Vehicle Dynamics

, 2013
A necessary stage in the development of traffic models is model validation, where the developed model is verified by comparing its outputs with observed data. The most frequently used variables are average value of speed, flow intensity and flow density (
Tomas Apeltauer, Holcner, Petr, Jiri Macur, Radimsky, Michal, Michal Radimsky, Macur, Jiri, Apeltauer, Tomas, Petr Holcner   +7 more
core   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Subarea Analysis Using A Travel Demand Model and A Microscopic Traffic Simulator

, 2004
This research proposes a method and related software tools to accomplish subarea analysis for transportation projects. The method proposed in this thesis takes output from the travel demand model and focuses in with a microscopic traffic simulation ...
Saur, Gregory John
core  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Traffic Simulation with MITSIMLab

, 2010
MITSIMLab (MIcroscopic Traffic SIMulation Laboratory) is a microscopic traffic simulation model that evaluates the impacts of alternative traffic management system designs at the operational level and assists in their subsequent refinement.
Koutsopoulos, Haris,, Moshe Ben-Akiva, Constantinos Antoniou, Tomer Toledo, Antoniou, Constantinos, Toledo, Tomer, Choundhury, Charisma, Yang, Qi, Balakrishna, Ramachandran, Qi Yang, Haris N. Koutsopoulos, Charisma F. Choudhury, Ramachandran Balakrishna, Ben-Akiva, Moshe   +13 more
core   +1 more source