Results 201 to 210 of about 3,115 (260)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

A multi-scenario evaluation of adaptive Fuzzy Logic Algorithms for intelligent traffic signal management in Urban intersections. [PDF]

Sci Rep
Shaheen S, Qadri SSSM, Riaz MB, Martinovic J, Dvorský J, Slaninová K.   +5 more
europepmc   +1 more source

Exact and metaheuristic approaches to minimizing makespan in parallel machine scheduling with conflicting jobs

International Transactions in Operational Research, EarlyView.
Abstract We address the scheduling conflicting jobs on parallel identical machines problem with makespan minimization, a classical and computationally challenging variant of parallel machine scheduling. We develop and evaluate three distinct solution methodologies: a novel constraint programming (CP) formulation, and two metaheuristics: a multi ...
Roberto Maria Rosati, Dinh Quy Ta, Minh Hoàng Hà, Andrea Schaerf   +3 more
wiley   +1 more source

Vibration Control and Micro-Forming Quality Guarantee of BMF-Based UHPC Wet Joints Under Traffic Loads Using Tuned Mass Dampers. [PDF]

Materials (Basel)
Wang Z, Zhang L, Zhou C, Wang P.
europepmc   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source

Reinforcement learning for dynamic speed control in connected and autonomous vehicles: A review of applications and challenges. [PDF]

iScience
Alhmiedat T, Albelwi S, Alotaibi M, Mustafa M, Alquier F, Gochoo M, Alnajjar F.   +6 more
europepmc   +1 more source

Integrating road safety and environmental impact via telematics: Modeling traffic accident risk using vehicle emissions

Journal of Risk and Insurance, EarlyView.
Abstract High‐emission private vehicles disproportionately contribute to urban air pollution and road accidents, both major public health threats and leading causes of death among young adults. Balancing individual driving behavior with collective environmental responsibility necessitates strategies that promote safer and cleaner driving.
Juan Sebastian Yanez, Montserrat Guillen, Paulina Roszkowska, Jens Perch Nielsen   +3 more
wiley   +1 more source

Reliable Transmission Optimization for UAV-Relayed Space-Air-Ground Integrated Vehicular Networks. [PDF]

Sensors (Basel)
Zong L, Cheng Y, Yao Y.
europepmc   +1 more source

Bilevel multiobjective control enhances arterial performance via spatiotemporal optimization of presignalized intersections. [PDF]

Sci Rep
Pan J, Yang Q, Li P.
europepmc   +1 more source

Bi-Level Simulation-Driven Optimization for Route Guidance in Disrupted Metro Networks via Hybrid Swarm Intelligence. [PDF]

Sensors (Basel)
Zheng X, Qin Y, Guo J, Sun X, Gao G.
europepmc   +1 more source