Results 201 to 210 of about 2,913 (260)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 4, Page 921-944, July 2026.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Predicting microscopic vehicle collision risks at toll plaza diverging area using bayesian dynamic logistic regressions. [PDF]

PLoS One
Li X, Fei Y, Jin K, Xing L, Zhang Y, Yang F, He S.   +6 more
europepmc   +1 more source

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2

Protein Science, Volume 35, Issue 7, July 2026.
Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das, Henry M. Mastrion, Harrison B. Vassar, Aditi Das   +3 more
wiley   +1 more source

Data-driven derivation of macroscopisc fundamental diagram from floating car trajectories. [PDF]

PLoS One
Lu X, Zhang J, He Q, Zheng S, Su J.
europepmc   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

Deep reinforcement learning for decision making of autonomous vehicle in non-lane-based traffic environments. [PDF]

PLoS One
Fei Y, Xing L, Yao L, Yang Z, Zhang Y.
europepmc   +1 more source

The Importance of Tire Wear Particles for Atmospheric Ice Nucleation

Geophysical Research Letters, Volume 53, Issue 12, 28 June 2026.
Abstract Tire wear particles (TWPs) are prevalent microplastic particles in the atmosphere and pose significant environmental and health risks to humans. Here, we investigated the ice nucleation activity (INA) of TWPs under mixed‐phase cloud conditions (∼−20.0°C < T < −5.0°C) and its changes caused by different environmental exposures, including UV and
Siyuan Jing, Kaiqi Wang, Yanting Wang, Shuling Chen, Jie Chen, Heike Wex, Thomas C. Wanger, Xianda Gong   +7 more
wiley   +1 more source

Enhancing Intersection Efficiency: A Comparative Analysis of Converting Single-Lane Roundabout to Turbo Roundabout. [PDF]

Sensors (Basel)
Čulík K, Kalašová A, Fabian P, Ondruš J.   +3 more
europepmc   +1 more source

Sparks of life: Enabling multi‐scale investigations of pro‐arrhythmic calcium‐handling abnormalities

The Journal of Physiology, EarlyView.
Melania Buonocunto, Jordi Heijman
wiley   +1 more source