Results 71 to 80 of about 5,316,321 (325)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On the magnetization textures in NiPd nanostructures

, 2011
We have observed peculiar magnetization textures in Ni$_{80}$Pd$_{20}$ nanostructures using three different imaging techniques: magnetic force microscopy, photoemission electron microscopy under polarized X-ray absorption, and scanning electron ...
Belkhou, Rachid, Bergeard, Nicolas, Chauleau, Jean-Yves, Locatelli, Andrea, McMorran, Benjamin, Mentes, Tevfik, Miltat, Jacques, Nino, Miguel, Rohart, Stanislas, Thiaville, Andre, Unguris, John   +10 more
core   +2 more sources

Software tools for automated transmission electron microscopy

Nature Methods, 2018
The demand for high-throughput data collection in electron microscopy is increasing for applications in structural and cellular biology. Here we present a combination of software tools that enable automated acquisition guided by image analysis for a ...
Martin Schorb, I. Haberbosch, W. Hagen, Y. Schwab, D. Mastronarde   +4 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Cochleates derived from Vibrio cholerae O1 proteoliposomes : The impact of structure transformation on mucosal immunisation [PDF]

, 2012
Cochleates are phospholipid-calcium precipitates derived from the interaction of anionic lipid vesicles with divalent cations. Proteoliposomes from bacteria may also be used as a source of negatively charged components, to induce calcium-cochleate ...
Adriana Callicó, Alexander B. Mullen, Bárbara Cedré, Caridad Zayas, David Mckee, Gunnar F. Kaufmann, José L. Pérez, Luis García, Oliver Pérez, Reinaldo Acevedo, Valerie A. Ferro   +10 more
core   +3 more sources

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains

Molecular Brain, 2021
Immunogold labeling allows localization of proteins at the electron microscopy (EM) level of resolution, and quantification of signals. The present paper summarizes methodological issues and experiences gained from studies on the distribution of synaptic
Jung-Hwa Tao-Cheng, Virginia Crocker, Sandra Lara Moreira, Rita Azzam   +3 more
doaj   +1 more source

Theory and applications of free-electron vortex states

, 2017
Both classical and quantum waves can form vortices: with helical phase fronts and azimuthal current densities. These features determine the intrinsic orbital angular momentum carried by localized vortex states.
Alonso, M. A., Bliokh, K. Y., Béché, A., Clark, L., Guzzinati, G., Ivanov, I. P., Juchtmans, R., Nori, F., Schattschneider, P., Van Boxem, R., Verbeeck, J.   +10 more
core   +1 more source

Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy

Cell and Tissue Research, 2011
This study describes a novel type of interstitial (stromal) cell — telocytes (TCs) — in the human and mouse respiratory tree (terminal and respiratory bronchioles, as well as alveolar ducts).
L. Popescu, M. Gherghiceanu, L. Suciu, C. Manole, M. Hinescu   +4 more
semanticscholar   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source