Results 151 to 160 of about 685,137 (258)

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling. [PDF]

Nat Struct Mol Biol
Veit S, Dearden GI, Menon KM, Noor F, Menon I, Morizumi T, Ernst OP, Menon AK, Pomorski TG.   +8 more
europepmc   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Image Tracing of Inflammatory Intestinal Organoids via Computational Clearing. [PDF]

Nanomaterials (Basel)
Jeon DG, Han MY, Lee H, Hwang H, Lee JM, Kim ES, Lee GH, Chang Y, Son MY, Park MJ, Nam SW.   +10 more
europepmc   +1 more source

Interstitium‐Mimicking Porous Alveolar Membranes Enable Physiologic Aerosol Transport and Distinct Acute‐Chronic Lung Injury Responses

Advanced Functional Materials, EarlyView.
An interstitium‐mimicking membrane combines three‐dimensional alveolar geometry, high pore interconnectivity, and mechanical compliance to overcome transport limitations of conventional lung‐on‐chip barriers. The resulting platform supports physiologic aerosol transport, quantitative analysis of cross‐barrier particle movement, and reveals divergent ...
Jae‐Won Choi, Sheng Zhang, Abbas Jalili, August Kohls, Woo‐Youl Maeng, Sikandar Azam, Wu Liu, Barbie Varghese, Yixin Zhao, Xi Ren, Shimin Liu, Si‐Yang Zheng   +11 more
wiley   +1 more source

Multispectral extended depth-of-field fluorescence microscopy with co-designed meta-optics and neural reconstruction. [PDF]

Light Sci Appl
Atalay Appak IA, Singh HJ, Korpela S, Ihalainen TO, Sahin E, Guillemot C, Caglayan H.   +6 more
europepmc   +1 more source

Spatially‐Resolved Coherence of Organic Molecular Spins at Room‐Temperature

Advanced Functional Materials, EarlyView.
Molecular spin qubits are emerging as a promising quantum sensing technology. This paper studies the variation in coherence and sensitivity in both crystalline and thin‐film samples by combining microscopy and room temperature optically detected coherent control.
Adrian Mena, Nicholas P. Sloane, Max R. Bonengel, Cameron M. Gould, Scott A. Sulway, Dane R. McCamey   +5 more
wiley   +1 more source

Imaging Techniques for the Study of Protein Condensates and Filaments and Their Applications. [PDF]

Int J Mol Sci
Shen X, Liu Y, Tan YW.
europepmc   +1 more source

Chemical Maturation Controls Bioavailability of Fetuin‐A‐Mineral Complexes in Biomineralization

Advanced Functional Materials, EarlyView.
The role of Fetuin‐A‐mineral complexes in matrix mineralization is unclear. Here, Fetuin‐A‐mineral complexes were found to exist in functionally distinct states that determine mineral bioavailability: chemically labile calciprotein monomers directly mineralize collagen fibrils, while chemically matured primary calciprotein particles require cellular ...
Judith M. Schaart, Luco Rutten, Shaina V. To, Alisha A. Shah, Martijn Martens, Elena Macías‐Sánchez, Willi Jahnen‐Dechent, Nico Sommerdijk, Anat Akiva   +8 more
wiley   +1 more source

Microfluidic point-of-care testing for antimicrobial resistance: advances, strategies, and One Health perspectives. [PDF]

Sci One Health
Wang C, Feng J, Zhou C, Xiu L, Hu Q, Li H, Guo X, Wang X, Chen M, Yin K.   +9 more
europepmc   +1 more source