Results 101 to 110 of about 2,728,882 (289)

In-situ confocal laser scanning microscopy of the solidification processes of white iron/steel composites

, 2012
The complex interaction between molten high chromium white cast iron and a mild steel substrate was studied. Confocal laser scanning microscopy permitted in situ imaging of the reacting phases while X-ray compositional mapping was used after the heat ...
Reid, Mark, Moran, Ken, Wuhrer, Richard (R17216), Cortie, Michael, Huggett, Paul, Lucey, Timothy   +5 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Advanced Fluorescence Microscopy Techniques-FRAP, FLIP, FLAP, FRET and FLIM [PDF]

, 2012
Fluorescence microscopy provides an efficient and unique approach to study fixed and living cells because of its versatility, specificity, and high sensitivity.
Ankerhold, Richard, Richard Ankerhold, Drummen, Gregor P. C., Gregor P. C. Drummen, Hellen C. Ishikawa-Ankerhold, Ishikawa-Ankerhold, Hellen C.   +5 more
core   +1 more source

Correlative x-ray microscopy and transmission electron microscopy for ultrastructural analysis of zebrafish tissue

Applied Microscopy
We established a correlative workflow combining X-ray microscopy (XRM) and transmission electron microscopy (TEM) to investigate the ultrastructure of zebrafish neuromasts.
Sun-Yeong Gwon, MinKi Choi, Ji Young Mun
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The effects of nanopillar and nanopit arrays on the morphology and osteogenic differentiation of adipose-derived stem cells

Applied Microscopy
Nanotopographic control of cell behavior offers great potential in designing biomimetic scaffolds for cell therapy. However, the behavior of cells on different nanotopographies is not fully understood.
Jihun Kang, Young-Shik Yun, Eun-Hye Kang, Jihye Lee, Deok-Jin Jeon, Seungmuk Ji, Yong-Oock Kim, In-Sik Yun, Jong-Souk Yeo   +8 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

CHARACTERIZATION OF OXIDIZED ZINC (CALAMINE) ORES BY SCANNING ELECTRON-MICROSCOPY AND ELECTRON-MICROPROBE ANALYSIS [PDF]

, 1986
Textural and structural features of Sardinian oxidized zinc (calamine) ores have been established by scanning electron microscopy and electron microprobe analysis, the elements analyzed being Zn, Pb, Ca and Fe.
Massacci, P., Bonifazi, G., BONIFAZI, Giuseppe, MASSACCI, Paolo   +3 more
core  

Histology and morphometry of the skin of the Korean ice goby Leucopsarion petersii (Gobiiformes, Gobiidae), in relation to its ecology and habitat

Applied Microscopy
The histological structure and morphometric characteristics of the skin of the Korean ice goby Leucopsarion petersii were investigated using light microscopy, two histological staining techniques, and SPSS statistical analysis. Skin samples from adult L.
Mu Sung Sung, Hyun Tae Kim
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source