Results 81 to 90 of about 2,728,882 (289)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies

Applied Microscopy
The development of bispecific antibodies (BsAbs) represents a significant advancement in therapeutic antibody design, enabling the simultaneous targeting of two different antigens.
Han-ul Kim, Young Kwan Kim
doaj   +1 more source

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

Applied Microscopy, 2020
Arthropods have an open circulatory system with a simple tubular heart, so it has been estimated that the contractile pumping structure of the cardiac muscle will be less efficient than that of vertebrates.
Yan Sun, Seung-Min Lee, Bon-Jin Ku, Myung-Jin Moon   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

python-microscopy/python-microscopy: Release 20.11.25

, 2020
The python-microscopy environment - an open-source package for light ...
Marin, Zach, Soeller, Christian, Hartwich, Tobias, Lin, Ruisheng, Lin, Yu, Baddeley, David, Philips, Mick, Pinto, David, Padron, David, Chung, Kenny, Barentine, Andrew, Graff, Michael, Balduf, Leo   +12 more
core   +1 more source

Anatomy and histology of the olfactory organ of the javelin goby Synechogobius hasta (Gobiiformes, Gobiidae)

Applied Microscopy
The olfactory organ of Synechogobius hasta was investigated with a focus on its environmental adaptation, using stereo microscopy and light microscopy. This research revealed the following anatomical and histological characteristics: (i) tubular anterior
Hyun-Tae Kim
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

ImageJ for Microscopy

BioTechniques, 2007
ImageJ is an essential tool for us that fulfills most of our routine image processing and analysis requirements. The near-comprehensive range of import filters that allow easy access to image and meta-data, a broad suite processing and analysis routine, and enthusiastic support from a friendly mailing list are invaluable for all microscopy labs and ...
openaire   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Noise reduction of electron holography observations for a thin-foiled Nd-Fe-B specimen using the wavelet hidden Markov model

Applied Microscopy
In this study, we investigate the effectiveness of noise reduction in electron holography, based on the wavelet hidden Markov model (WHMM), which allows the reasonable separation of weak signals from noise.
Sujin Lee, Yoshihiro Midoh, Yuto Tomita, Takehiro Tamaoka, Mitsunari Auchi, Taisuke Sasaki, Yasukazu Murakami   +6 more
doaj   +1 more source