Results 91 to 100 of about 2,802,077 (293)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy [PDF]
, 2003 Dynamic visualization of the intravascular events leading to the extravasation of leukocytes into tissues by intravital microscopy has significantly expanded our understanding of the underlying molecular processes.
Kuebler, Wolfgang M. +4 more
core +1 more source
BioTechniques, 2007 ImageJ is an essential tool for us that fulfills most of our routine image processing and analysis requirements. The near-comprehensive range of import filters that allow easy access to image and meta-data, a broad suite processing and analysis routine, and enthusiastic support from a friendly mailing list are invaluable for all microscopy labs and ...
openaire +3 more sources
Applied MicroscopyIn this study, we investigate the effectiveness of noise reduction in electron holography, based on the wavelet hidden Markov model (WHMM), which allows the reasonable separation of weak signals from noise.
Sujin Lee +6 more
doaj +1 more source
Applied Microscopy, 2020 Arthropods have an open circulatory system with a simple tubular heart, so it has been estimated that the contractile pumping structure of the cardiac muscle will be less efficient than that of vertebrates.
Yan Sun +3 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
3D solutions in transmission electron (Cryo) -microscopy in biology [PDF]
, 2012 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166One of the main problems in transmission electron microscopy in the biological field is the tri-dimensionality.
Muela, Yolanda +4 more
core +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Application of multiline two-photon microscopy to functional in vivo imaging [PDF]
, 2006 Kurtz R, Fricke M, Kalb J, Tinnefeld P, Sauer M. Application of multiline two-photon microscopy to functional in vivo imaging. Journal of Neuroscience Methods.
Kalb, J +4 more
core +1 more source