Results 121 to 130 of about 8,924,569 (266)
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Compact waterwindow transmission X-ray microscopy
, 2000 microscopy, water window, zone plate optics. Summary We demonstrate sub-100 nm resolution water-window soft X-ray full-®eld transmission microscopy with a compact system. The microscope operates at l3.37 nm and is based on a 100 Hz table-top regenerative
Rymell, L. +9 more
core +1 more source
Malaria JournalBackground Malaria continues to be endemic within Haiti, despite numerous strategies to reduce its incidence. In 2012, malaria surveillance in clinical settings shifted away from microscopy to HRP2 based Rapid Diagnostic Tests (RDTs) as the primary form ...
Graham A. Matulis +17 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Imaging Tissue Engineering Scaffolds Using Multiphoton Microscopy
, 2011 In this study, we combined two-photon autofluorescence and second harmonic generation imaging to investigate the three- dimensional microstructure and nonlinear optical properties of tissue engineering scaffolds.
SUN, YEN;TAN, HSIN-YUAN;LIN, SUNG-JAN;LEE, HSUAN-SHU;LIN, TZU-YU;JEE, SHIOU-HWA;YOUNG, TAI -HORNG;LO, WEN;CHEN, WEI-LIANG;DONG, CHEN-YUAN +1 more
core +1 more source
International Journal of Infectious DiseasesIntroduction: Mycobacterial culture is considered the reference standard for the detection of mycobacteria, including nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTBC). However, it is time-consuming and costly.
Dr Leong Tung Ong +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
, 2014 Electronic microscopy has been used for morphology evaluation of different materials structures. However, microscopy results may be affected by several factors. Image processing methods can be used to correct and improve the quality of these results.
De Siqueira, Alexandre Fioravante +7 more
core +1 more source
Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin +11 more
wiley +1 more source