Results 91 to 100 of about 74,782 (341)

Do Flame Retardants Promote Vitamin D Deficiency? [PDF]

, 2014
Vitamin D deficiency in the Unites States has become more prevalent in recent years. Research has shown that environmental chemicals such as flame-retardants induce hepatic enzymes in the cytochrome P450 family such as CYP24 and CYP3A that are important ...
Petteruti, Audrey
core   +2 more sources

Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. [PDF]

, 2012
The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions.
ALESSI, Nicola, CABIBI, Daniela, MACALUSO, Fabio Salvatore   +2 more
core   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

Neurobiology of Disease, 2018
α-synuclein (αS) is a small protein that self-aggregates into α-helical oligomer species and subsequently into larger insoluble amyloid fibrils that accumulate in intraneuronal inclusions during the development of Parkinson's disease.
Emanuela Colla, Giulia Panattoni, Alessio Ricci, Caterina Rizzi, Lucia Rota, Nicola Carucci, Verdiana Valvano, Francesco Gobbo, Simona Capsoni, Michael K. Lee, Antonino Cattaneo   +10 more
doaj   +1 more source

Anti-liver-kidney microsome antibody recognizes a 50,000 molecular weight protein of the endoplasmic reticulum

Journal of Experimental Medicine, 1985
Children with autoimmune chronic active hepatitis may have high titers of antibodies detected by immunofluorescence staining of hepatocytes and tubular cells in rat liver and kidney sections, respectively.
F. Alvarez, O. Bernard, J. Homberg, G. Kreibich   +3 more
semanticscholar   +1 more source

Microsomal epoxide hydrolase polymorphisms

Molecular Medicine Reports, 2010
Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in exons 3 and 4 of the microsomal epoxide hydrolase gene that change tyrosine residue 113 to histidine (Tyr113His) and histidine 139 to arginine (His139Arg), respectively.
Pinarbasi, Hatice, Silig, Yavuz, Pinarbasi, Ergun   +2 more
openaire   +6 more sources

Ca2+ uptake to purified secretory vesicles from bovine neurohypophyses [PDF]

, 1982
Purified secretory vesicles isolated from bovine neurohypophyses were found to take up Ca2+ when incubated at 30°C in media containing 10−7 to 10−4 M free Ca2+. At 10−4 free Ca2+ 19 nmol/mg protein were taken up within 30 min.
Baker, Banks, Barer, Blaustein, Borle, Bowman, Böhlen, Conigrave, Crompton, Dicker, Ginsburg, Gratzl, Gratzl, Heidemarie I. Krieger-Brauer, Krieger-Brauer, Krieger-Brauer, Lehninger, Lehninger, Manfred Gratzl, Morris, Niels A. Thorn, Normann, Olsen, Pressman, Rasmussen, Robinson, Russell, Saermark, Thorn, Thorn, Torben Særmark, Torp-Pedersen, Torp-Pedersen, Vilhardt, Vilhardt, Weiss   +35 more
core   +1 more source

Permeability of 16 Straight‐ and Branched‐Chain Parabens Using the Caco‐2 Assay

Journal of Applied Toxicology, EarlyView.
ABSTRACT The in vitro intestinal permeability of straight‐ and branched‐chain parabens has not been extensively investigated. Sixteen parabens were tested in the Caco‐2 assay. Passive diffusion was measured using PAMPA. The transport of the MCT1 substrate, p‐coumaric acid, as well as propylparaben and isopropylparaben, was investigated.
Nicola J. Hewitt, Manuela Mayer, Andreas Schepky, Corie Ellison   +3 more
wiley   +1 more source

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Journal of Lipid Research, 2000
Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-{N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino}-1,1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and ...
Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Issei Ohtsuka, Ichiro Yoshida, Takao Saeki, Hiroshi Tanaka   +6 more
doaj   +1 more source

Microsomes are the in vitro ER

The Journal of Cell Biology, 2005
![Graphic][1] Microsomes (here) and ER look similar, and both have ribosomes (see dots near “ob2”). PALADEThe abundance of electron microscope (EM) images in the 1940s and 1950s brought a new problem: nomenclature. What to call all those black smudges?
openaire   +3 more sources