Results 171 to 180 of about 32,983 (314)
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano +2 more
wiley +2 more sources
The FEBS Journal, EarlyView.Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti +9 more
wiley +1 more source
Activation of Protein Synthesis by Microsomes from Aging Beet Disks
, 1967 R. John Ellis, I. R. MACDONALD
openalex +2 more sources
Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen +6 more
wiley +2 more sources
Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis
New Phytologist, EarlyView.Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Scott Galeung Alexander Mann +6 more
wiley +1 more source
7α-Hydroxylation of cholestanol by rat liver microsomes
, 1968 Sarah Shefer +2 more
openalex +1 more source
Enzymic formation of oestrone 3-glucuronide by rabbit-liver microsomes [PDF]
, 1963 Smith Er, H. Breuer
openalex +1 more source
Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy. [PDF]
PharmaceuticsWen D, Chen B, Deng M, Wu S, Xie S.
europepmc +1 more source
Sorbitol and NaCl stresses affect free, microsome-associated and thylakoid-associated polyamine content in Zea mays and Phaseolus vulgaris [PDF]
, 2011 Ewa Sobieszczuk-Nowicka, Jolanta Legocka
core +1 more source
Experimental Physiology, EarlyView.Abstract In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non‐lipid precursors, intrahepatic lipid droplets and recycling ...
Kieran Smith +2 more
wiley +1 more source