Results 171 to 180 of about 63,135 (311)

EFFECT OF PHENOBARBITAL AND METHYLCHOLANTHRENE TREATMENT ON DRUG-INDUCED DIFFERENCE SPECTRUM OF LIVER MICROSOMES

, 1969
Ryuichi Kato, Akira Takanaka
openalex   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, Volume 65, Issue 8, Page 1026-1038, August 2025.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT The organic anion transporting polypeptide (OATP) 2B1 is expressed in pharmacokinetically relevant organs such as the liver, the kidney, and the small intestine and it is known to transport a broad range of substrates including statins. In pharmacokinetic studies applying two rat models—one deficient for rat Oatp2b1 and the other expressing ...
Jonny Kinzi, Janine Hussner, Isabell Seibert, Marta Rysz, Valerio Taggi, Simone Zuercher, Annika Tillmann, Oliver Schwardt, Stefan Oswald, Daniel Ricklin, Henriette E. Meyer zu Schwabedissen   +10 more
wiley   +1 more source

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set. [PDF]

Pharmaceuticals (Basel)
Maurer CK, Fang Z, Duevel HM, Harlfinger S, Petersson C.   +4 more
europepmc   +1 more source

Overlapping but distinct specificities of anti‐liver‐kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes

Clinical and Experimental Immunology, 1999
Reinhild Klein, U. M. Zanger, Thomas Berg, Uwe Hopf, Peter A. Berg   +4 more
semanticscholar   +1 more source

Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes [PDF]

, 1964
E. Boyland, Masayuki Kimura, Peter Sims
openalex   +1 more source

Extending Investigations of miR‐126‐5p on the Regulation of CYP2A6, the Major Nicotine‐Inactivating Enzyme

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT CYP2A6 is the hepatic enzyme responsible for the metabolic inactivation of nicotine. Variation in CYP2A6 alters nicotine clearance, affecting numerous smoking behaviors and tobacco‐related diseases, making investigating sources of variation important.
Weilong Gu, Alec W. R. Langlois, Haidy Giratallah, Katrina G. Claw, Bhagwat Prasad, Kenneth E. Thummel, Rachel F. Tyndale   +6 more
wiley   +1 more source

Studies of <i>Piper auritum</i> Kuntz's Mutagenic and Antimutagenic Properties Using the Ames Test. [PDF]

Metabolites
Muñoz-Carrillo LS, Madrigal-Bujaidar E, Hernández-Ojeda SL, Morales-González JA, Madrigal-Santillán EO, Álvarez-González I, Espinosa-Aguirre JJ.   +6 more
europepmc   +1 more source

EFFECT OF PHENOBARBITAL ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES AND ELECTRON TRANSPORT SYSTEM OF LIVER MICROSOMES IN ALLOXAN DIABETES AND THYROXINE TREATED RATS

, 1969
Ryuichi Kato, Atsushi Takahashi
openalex   +1 more source

Studies on phospholipids. 8. Phospholipids in rat-liver mitochondria and microsomes [PDF]

, 1961
F. D. Collins, Valerie L. Shotlander
openalex   +1 more source