Results 211 to 220 of about 63,135 (311)

Current practice, challenges and future opportunities in the safety assessment of newly expressed proteins in genetically modified plants

EFSA Journal, Volume 23, Issue 8, August 2025.
Abstract Current risk assessment strategies for protein safety of newly expressed proteins (NEPs) in genetically modified (GM) plants are based on chemical risk assessment principles and Codex Alimentarius guidelines for biotech‐derived foods, initially published in 2003. These guidelines were designed for proteins with multiple testing options and for
EFSA Panel on Genetically Modified Organisms (GMO), Josep Casacuberta, Francisco Barro, Albert Braeuning, Ruud de Maagd, Michelle M. Epstein, Thomas Frenzel, Jean‐Luc Gallois, Frits Koning, Antoine Messéan, F. Javier Moreno, Fabien Nogué, Giovanni Savoini, Alan H. Schulman, Christoph Tebbe, Eve Veromann, Michele Ardizzone, Luca Belmonte, Martina Bonatti, Ian Dewhurst, Ivan Dimitrov, Arianna Ferrari, Tilemachos Goumperis, Kevin Hogeveen, Aleksandra Lewandowska, Robin Ornsrud, Nikoletta Papadopoulou, Konstantinos Paraskevopoulos, Tommaso Raffaello, Reinhilde Schoonjans, Elisabeth Waigmann, Elena Sánchez‐Brunete, Antonio Fernandez Dumont   +32 more
wiley   +1 more source

From IP3RPEP6 Inhibition of IP₃ receptor channels to insights: do channel subunits collaborate or cooperate? [PDF]

Cell Mol Life Sci
Witschas K, Tao S, Leybaert L.
europepmc   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility. [PDF]

J Med Chem
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius D, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP.   +19 more
europepmc   +1 more source

Comparing Soy and Milk Protein Regulation of Hepatic Omega‐3 Fatty Acid Biosynthesis

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
EPA and DHA are omega‐3 fatty acids with anti‐inflammatory and triglyceride‐lowering properties. They are obtained from fatty fish or synthesized in the liver from ALA. Male C57BL/6N mice were fed a diet containing soy protein isolate or skim milk powder and 1% or 3% energy from ALA for 8 weeks.
Melissa Gonzalez‐Soto, Siobhan E. Woods, Blair W. MacLeod, James N. Smorenburg, Geneviève J. DesOrmeaux, Graham P. Holloway, Ruxandra D. Rotarescu, Miranda R. Green, Adam H. Metherel, David M. Mutch   +9 more
wiley   +1 more source

Development and evaluation of deuterated [¹⁸F]JHU94620 isotopologues for the non-invasive assessment of the cannabinoid type 2 receptor in brain. [PDF]

EJNMMI Radiopharm Chem
Gündel D, Maqbool M, Teodoro R, Ludwig FA, Heerklotz A, Toussaint M, Deuther-Conrad W, Bormans G, Brust P, Kopka K, Moldovan RP.   +10 more
europepmc   +1 more source

A Second Ouabain-sensitive Sodium-dependent Adenosine Triphosphatase in Brain Microsomes

, 1969
Arthur H. Neufeld, Harvey M. Levy
openalex   +1 more source

The effects of CYP2B6 inactivators on the metabolism of ciprofol. [PDF]

PLoS One
Lu M, Zhang X, Li W, Li X, Li S, Yin X, Zhang Z.   +6 more
europepmc   +1 more source

Amino Acid Incorporation in Vitro by Ribonucleoprotein Particles Detached from Guinea Pig Liver Microsomes

, 1960
Jack F. Kirsch, Philip Siekevitz, George E. Palade   +2 more
openalex   +1 more source

Structure confirmation, reactivity, bacterial mutagenicity and quantification of 2,2,4-tribromo-5-hydroxycyclopent-4-ene-1,3-dione in drinking water. [PDF]

Commun Chem
Ciccarelli D, Lancaster BMJ, Braddock DC, Calvaresi M, Mišík M, Knasmüller S, Mattioli EJ, Zerbetto F, White AJP, Marczylo T, Gant TW, Barron LP.   +11 more
europepmc   +1 more source