Results 211 to 220 of about 32,983 (314)

Amino Acid Incorporation in Vitro by Ribonucleoprotein Particles Detached from Guinea Pig Liver Microsomes

, 1960
Jack F. Kirsch, Philip Siekevitz, George E. Palade   +2 more
openalex   +1 more source

MORPHOLOGICAL AND BIOCHEMICAL CORRELATES OF CEREBRAL MICROSOMES [PDF]

, 1965
F. de Balbian Verster, Otto Z. Sellinger, James C. Harkin   +2 more
openalex   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, Volume 65, Issue 6, Page 715-730, June 2025.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Purification and Properties of an Enzyme in Human Blood and Rat Liver Microsomes Catalyzing the Formation and Hydrolysis of γ-Lactones

, 1966
William N. Fishbein, Samuel P. Bessman
openalex   +1 more source

Changes in the chemical composition and the enzymic activities of hepatic microsomes of the chick embryo during development [PDF]

, 1967
JK Pollak, DB Ward
openalex   +1 more source

A novel system to determine activity of individual uridine 5'-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads. [PDF]

J Biol Chem
Wang T, Taub ME, Chan TS.
europepmc   +1 more source

The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele‐Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma Receiving Doxorubicin via Transarterial Chemoembolization

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT We investigated the influence of CYP2B6, GSTP1, and SLCO1B1 star allele‐predicted phenotypes and CBR1 variants on clinical outcomes in patients with HCC receiving DOX via TACE. A prospective cohort of patients with HCC underwent DOX therapy via TACE.
Sireen Abdul Rahim Shilbayeh, Omnia A. Abd El‐Baset, Mohammad A. Alshabeeb, Abdalrhman Hamdan Alanizi, Naglaa F. Khedr, Rehab H. Werida   +5 more
wiley   +1 more source

Inhibitors of Protein Synthesis in Rat Liver Microsome Fractions

, 1967
Oscar A. Scornik, Mahlon B. Hoagland, Lorraine C. Pfefferkorn, Elizabeth Bishop   +3 more
openalex   +1 more source

Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility. [PDF]

J Med Chem
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius D, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP.   +19 more
europepmc   +1 more source

The Effects of Different Administration Regimens of Berberine Hydrochloride on the Pharmacokinetics of Sirolimus in Rats

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Sirolimus is a third‐generation immunosuppressant with multiple efficacies, including antifungal, antitumor, and immunosuppressive properties. We conducted a pharmacokinetic study to determine the effect of berberine hydrochloride (BBR) on the pharmacokinetics of sirolimus in rats.
Yuanxia Yang, Yue Zhang, Yingdong Qu, Liwan Cui   +3 more
wiley   +1 more source