Results 221 to 230 of about 32,983 (314)

Development and evaluation of deuterated [18F]JHU94620 isotopologues for the non-invasive assessment of the cannabinoid type 2 receptor in brain. [PDF]

open access: yesEJNMMI Radiopharm Chem
Gündel D   +10 more
europepmc   +1 more source

Assessments of CYP‐Inhibition‐Based Drug–Drug Interactions Between Tofacitinib and Lipid‐Lowering Agents in Rats Both In Vitro and In Vivo

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Tofacitinib is a widely used medication for the treatment of arthritis. It has been reported that some patients experience abnormal cholesterol levels following treatment, leading to recommendations for the coadministration of lipid‐lowering drugs such as statins.
Hang Yang   +9 more
wiley   +1 more source

Structure confirmation, reactivity, bacterial mutagenicity and quantification of 2,2,4-tribromo-5-hydroxycyclopent-4-ene-1,3-dione in drinking water. [PDF]

open access: yesCommun Chem
Ciccarelli D   +11 more
europepmc   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez   +17 more
wiley   +1 more source

The effects of CYP2B6 inactivators on the metabolism of ciprofol. [PDF]

open access: yesPLoS One
Lu M   +6 more
europepmc   +1 more source

Current insights into pathogenesis and anti‐inflammatory treatment strategies for severe alcohol‐associated hepatitis: focus on neutrophil‐targeted therapies

open access: yesHepatology Research, Volume 55, Issue 6, Page 785-794, June 2025.
Abstract Alcohol‐associated hepatitis (AH) is the leading cause of liver‐related mortality, with severe alcohol‐associated hepatitis (SAH) showing a short‐term mortality rate of 20%–50% even in developed countries. Corticosteroids are the only evidence‐based pharmacologic treatment, but their efficacy is limited to short‐term survival, with 30%–40% of ...
Ryosuke Kasuga   +3 more
wiley   +1 more source

Some Physicochemical Properties of Ribonucleoprotein from Rat Liver Microsomes

open access: hybrid, 1962
Mary G. Hamilton   +2 more
openalex   +1 more source

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