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Flavonoids as CYP3A4 Inhibitors In Vitro. [PDF]

open access: yesBiomedicines
Kondža M, Brizić I, Jokić S.
europepmc   +1 more source
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The preparation of microsomes

Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie, 1965
Various methods of disrupting liver cells and preparing microsomes were studied. The quality and yield of the microsomes in the preparations was judged by the NADPH-dependent N- and p-hydroxylation of N-ethylaniline, protein content, and cyanide-sensitive respiration.
Hermann G. Kampffmeyer   +2 more
openaire   +3 more sources

Microsomal metabolism of fluoroanilines

Xenobiotica, 1989
1. The microsomal, cytochrome P-450-dependent metabolism of fluoroanilines was studied using 19F-n.m.r. and also by a chemical assay for the hydroxy derivatives. 2. 2-Fluoro- and 3-fluoroaniline were preferentially hydroxylated at the para-position. 3. 4-Fluoroaniline was both p- and o-hydroxylated to a significant extent. 4.
Rietjens, I.M.C.M., Vervoort, J.
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Effect of thiourea on microsomal oxidation alcohols and associated microsomal functions [PDF]

open access: possibleBiochemistry, 1979
Thiourea and diethylthiourea, two compounds which react with hydroxyl radicals, inhibited NADPH-dependent microsomal oxidation of ethanol and 1-butanol. Inhibition by both compounds was more effective in the presence of the catalase inhibitor, azide.
Elisa Dicker   +3 more
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Fusion of microsomal vesicles

Experientia, 1978
Studies which indicate the fusion of rat liver microsomal vesicles show that the rate of fusion of microsomal vesicles, as revealed by electron microscopic examinations, is dependent on the fusion temperature and the amount of detergent present in the microsomal suspension.
H. U. Schulze, Liliane Pop
openaire   +3 more sources

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