Results 51 to 60 of about 50,037 (190)

Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism

Pharmaceutical Biology, 2018
Context: Asiatic acid has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.
Ling Guo, Ying Cui, Kaijun Hao
doaj   +1 more source

Biotransformation of Abiraterone Into Five Characteristic Metabolites by the Rat Gut Microbiota and Liver Microsomes

Frontiers in Oncology, 2022
It is well known that the role of gut microbiota in drug metabolism, especially in oral difficult absorbable drugs. Understanding the gut microbiota could enable us to understand drugs in new ways.
Adili Keranmu, Adili Keranmu, Fei-Ya Yang, Wasilijiang Wahafu, Su-Jun Han, Guo-Sheng Yang, Nian-Zeng Xing, Nian-Zeng Xing   +7 more
doaj   +1 more source

Induction of humoral and cellular immune responses against the HIV-1 envelope protein using γ-retroviral virus-like particles

Virology Journal, 2011
This study evaluates the immunogenicity of the HIV envelope protein (env) in mice presented either attached to γ-retroviral virus-like-particles (VLPs), associated with cell-derived microsomes or as solubilized recombinant protein (gp160).
Purcell Damian FJ, Center Robert J, Pedersen Finn S, Bahrami Shervin, Melchjorsen Jesper, Wheatley Adam, Kirkegaard Tea, Ostergaard Lars, Duch Mogens, Tolstrup Martin   +9 more
doaj   +1 more source

Comparative chemical and biological hydrolytic stability of homologous esters and isosteres

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. Their presence is often associated with hydrolytic lability.
Hygor M. R. de Souza, Jéssica S. Guedes, Rosana H. C. N. Freitas, Luis G. V. Gelves, Harold H. Fokoue, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro, Lidia M. Lima   +7 more
doaj   +1 more source

The di-flavoenzyme reductase directly activates oxygen for the metabolism of diverse drug molecules by liver microsomal Cytochrome P450s [PDF]

arXiv, 2006
This submission has been withdrawn by arXiv administration due to complaints of misuse of institutional affiliation.
arxiv  

2-fenilbenzotriazóis (PBTA): uma nova classe de contaminantes ambientais 2-phenylbenzotriazoles (PBTAs): a new class of environmental contaminants

Química Nova, 2008
This work is a literature review of PBTAs, the phenylbenzotriazoles generated from the reduction and chlorination of azo dyes. The PBTAs and the non- chlorinated PBTAs were isolated for the first time from river blue rayon organic extracts that showed ...
Fábio Kummrow, Gisela de Aragão Umbuzeiro   +1 more
doaj   +1 more source

Overlapping but distinct specificities of anti‐liver‐kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes

Clinical and Experimental Immunology, 1999
Anti‐liver‐kidney microsome antibodies (anti‐LKM) occur in autoimmune hepatitis (AIH) type II and in a subset of patients with hepatitis C. Anti‐LKM1 in AIH are directed against cytochrome P4502D6 (CYP2D6), but conflicting data exist concerning the ...
Reinhild Klein, U. M. Zanger, Thomas Berg, Uwe Hopf, Peter A. Berg   +4 more
semanticscholar   +1 more source

The evolution and structure of biomedical knowledge on cytochrome P450 [PDF]

arXiv, 2017
Cytochrome P450 are fundamental proteins to the metabolism of drugs and other relevant processes. through a combination of text mining and network analysis of the P450 literature we mapped the emergence and evolution of the biomedical research communities working on this family of proteins.
arxiv  

Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism

Pharmaceutical Biology, 2019
Context: Paeoniflorin is reported to possess numerous pharmacological activities. Paeoniflorin and glycyrrhizin are always used together for the treatment of disease in China clinics; however, the drug–drug interaction between glycyrrhizin and ...
Hongjuan Sun, Jingfeng Wang, Juan Lv
doaj   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production [PDF]

Journal of Neuroimmunology 174(1-2): 39-51 (2006), 2007
In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other
arxiv