Results 51 to 60 of about 74,782 (341)

The Influence of CYP3A4 Genetic Polymorphism and Proton Pump Inhibitors on Osimertinib Metabolism

Frontiers in Pharmacology, 2022
The aim of this study was to 1) investigate the effects of 27 CYP3A4 variants on the metabolism of osimertinib and 2) study the interactions between osimertinib and others as well as the underlying mechanism.
Nanyong Gao, Xiaodan Zhang, Xiaodan Zhang, Xiaoqin Hu, Qihui Kong, Jianping Cai, Guoxin Hu, Jianchang Qian   +7 more
doaj   +1 more source

Interactions Between Active Matters and Endogenous Fields

Advanced Materials, EarlyView.
This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin, Qiaoxin Guan, Jiangqi Feng, Shuqin Chen, Leilei Xu, Jianguo Guan, Samuel Sánchez   +6 more
wiley   +1 more source

Analyzing the topology of N-linked glycans by PNGase F accessibility assay

STAR Protocols, 2023
Summary: While N-glycans are synthesized in the lumens, some of them reach the cytosolic side of membranes through retro-translocation independent of endoplasmic-reticulum-associated degradation.
Jingcheng Wang, Jin Ye
doaj   +1 more source

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response [PDF]

, 2012
Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage
A Bertolotti, AK Leung, BD Hamman, C Sidrauski, D Ron, E Pedrazzini, H Harding, H Kleine, H Lorenz, HP Harding, I Kim, J Ménissier-de Murcia, JD Malhotra, L Zheng, M Calfon, M Malanga, M Schuldiner, Miri Jwa, MO Hottiger, N Borgese, P Chang, P Walter, P Whitley, Paul Chang, PO Hassa, R Sriburi, S Di Paola, SB Stephens, V Schreiber, Y Kimata   +29 more
core   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]

, 2018
BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K, Fitzpatrick, Rikki L, Gustafson, Daniel L, Quimby, Jessica M, Ramirez, Dominique, Sieberg, Liberty G, Wittenburg, Luke A   +6 more
core  

Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum). [PDF]

, 2017
Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins
Tian, Li, Wu, Sheng
core   +2 more sources

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

Molecules, 2015
Geissoschizine methyl ether (GM) is an indole alkaloid found in Uncaria hook, which is a galenical constituent of yokukansan, a traditional Japanese medicine. GM has been identified as the active component responsible for anti-aggressive effects. In this
Hirotaka Kushida, Takashi Matsumoto, Yasushi Igarashi, Hiroaki Nishimura, Junko Watanabe, Kazuya Maemura, Yoshio Kase   +6 more
doaj   +1 more source

The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO- and t-BOOH-induced mutagenesis in coli [PDF]

Archives of Biological Sciences, 2011
The aim of this work was to investigate the antimutagenic potential of monoterpenes from sage and basil in Escherichia coli. The mutagenic potential of monoterpenes was pre-screened with Salmonella/microsome reversion assay in strain TA100 and no ...
Nikolić Biljana, Mitić-Ćulafić Dragana, Vuković-Gačić Branka, Knežević-Vukčević Jelena   +3 more
doaj   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +2 more sources