Results 51 to 60 of about 11,599 (234)
Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs
Brazilian Journal of Medical and Biological Research, 2004 The GLUT4 transporter plays a key role in insulin-induced glucose uptake, which is impaired in insulin resistance. The objective of the present study was to investigate the tissue content and the subcellular distribution of GLUT4 protein in 4- to 12-year-
A.M. Vargas +5 more
doaj +1 more source
Changes of microsomal membrane compositions modulate microsomal enzyme activity [PDF]
Pediatric Research, 1979 We have shown previously, that the activity of cerebrosulfotransferase (CST) a microsomal enzyme involved in myelin synthesis is modulated in vitro by the cholesterol-phospholipid ratio (C/P) in microsomal membranes. To further investigate this mechanism, we studied two different models: 1.) Removal of cholesterol by phospholipid micelles and 2 ...
N Herschkowitz +3 more
openaire +1 more source
Animal Research and One Health, EarlyView.Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao +12 more
wiley +1 more source
Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism
Pharmaceutical Biology, 2018 Context: Asiatic acid has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.
Ling Guo, Ying Cui, Kaijun Hao
doaj +1 more source
Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells [PDF]
Archives of Biological Sciences, 2005 The inhibition of spontaneous and UV-induced mutations by essential oil (EO) of sage (Salvia officinalis L.) and its fractions F1-F5 containing different proportions of mono- and sesquiterpenes was studied with the Salmonella/microsome, E.
Knežević-Vukčević Jelena B. +5 more
doaj +1 more source
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Comparative chemical and biological hydrolytic stability of homologous esters and isosteres
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. Their presence is often associated with hydrolytic lability.
Hygor M. R. de Souza +7 more
doaj +1 more source
Animal Research and One Health, EarlyView.Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin +6 more
wiley +1 more source
Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics
Biotechnology and Bioengineering, EarlyView.ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu +4 more
wiley +1 more source
Virology Journal, 2011 This study evaluates the immunogenicity of the HIV envelope protein (env) in mice presented either attached to γ-retroviral virus-like-particles (VLPs), associated with cell-derived microsomes or as solubilized recombinant protein (gp160).
Purcell Damian FJ +9 more
doaj +1 more source