Results 281 to 290 of about 1,677,689 (317)
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Drug Metabolism And Disposition, 2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported.
Y. Hijazi, R. Boulieu
semanticscholar +1 more source
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many cases of ketamine illegal consumption were reported.
Y. Hijazi, R. Boulieu
semanticscholar +1 more source
Kavalactone Metabolism in Rat Liver Microsomes
Phytotherapy Research, 2011The specific CYP enzymes involved in kavalactone (KLT) metabolism and their kinetics have not been fully examined. This study used rat liver microsomes (RLM) to determine kavain (KA), methysticin (MTS) and desmethoxyyangonin (DMY) enzyme kinetic parameters, to elucidate the major CYP450 isoforms involved in KLT metabolism and to examine gender ...
Anthony Rowe, Iqbal Ramzan, Shuang Fu
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The mechanism of liver microsomal lipid peroxidation
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975In the presence of Fe-3+ and complexing anions, the peroxidation of unsaturated liver microsomal lipid in both intact microsomes and in a model system containing extracted microsomal lipid can be promoted by either NADPH and NADPH : cytochrome c reductase or by xanthine and xanthine oxidase.
Steven D. Aust, Thomas C. Pederson
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
Donald D. Koblin +2 more
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FRACTIONATION OF MOUSE LIVER MICROSOMAL ESTERASES
Canadian Journal of Biochemistry, 1965Mouse liver microsomal esterases were fractionated on DEAE-cellulose after the solution of these enzymes in a solution containing 0.1 M glycyl glycine buffer, pH 7.0, and 5 × 10−4 M Lubrol W, a nonionic detergent. Elution of the enzymes from the DEAE-cellulose was accomplished by using NaCl in the glycyl glycine – Lubrol W solution.
C. Carruthers, E. Heins, A. Baumler
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A microsomal exoribonuclease from rat liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1979A exoribonuclease has been purified from the microsomes of rat liver. The enzyme had an apparent molecular weight of 80 000-83 000 and produced, via a processive mechanism, 5'-AMP as the only product from poly(A). The degradation was found to proceed in the 3' to 5' direction.
Kazuei Igarashi +4 more
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Esterification of cholesterol in rat liver microsomes
Archives of Biochemistry and Biophysics, 1964Washed rat liver microsomes esterify cholesterol in the presence of added ATP and CoA; net synthesis of cholesterol esters was demonstrated. The optimum pH of the reaction was between 6.8 and 7.2; the effects of time and concentration of substrate were investigated.
M.D. Law +5 more
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Metabolism of doxophylline by rat liver microsomes.
Drug Metabolism and Disposition, 1986The metabolic transformation of the bronchospasmolytic agent doxophylline (2-(7'-theophyllinemethyl)-1,3-dioxolane) was studied in vitro with phenobarbital-induced rat liver microsomal fraction containing the NADPH-generating system. Doxophylline was poorly metabolized as 95% of the recovered material was parent compound. The major metabolite resulted:
GROSA, Giorgio +2 more
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The interaction of cimetidine with rat liver microsomes
Biochemical Pharmacology, 1983The binding of cimetidine to rat liver microsomes in M/15 phosphate buffer, pH 7.9, has been investigated by difference spectroscopy and also by equilibrium partition studies, the latter method providing the more definitive characterization of the interaction in the pharmacologically relevant, low micromolar range of drug concn. In addition, the effect
Reilly P.E.B. +2 more
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Xenobiotica; the fate of foreign compounds in biological systems, 2019
Laura Hedges +6 more
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Laura Hedges +6 more
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