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Metabolism of Dietary Flavonoids in Liver Microsomes
Current Drug Metabolism, 2013Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4'-, C-3', C-6 and C-8- position when there is a single or no hydroxy group ...
Jianbo, Xiao, Petra, Högger
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THE MECHANISM OF SCHRADAN ACTIVATION BY LIVER MICROSOMES
Canadian Journal of Biochemistry and Physiology, 1957The mechanism by which schradan is converted to a powerful anticholinesterase by fortified liver homogenates has been studied. A scheme is proposed involving the production from DPNH of hydrogen peroxide, which then oxidizes an unknown microsomal factor with the aid of catalase. The factor in turn oxidizes schradan.
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FRACTIONATION OF MOUSE LIVER MICROSOMAL ESTERASES
Canadian Journal of Biochemistry, 1965Mouse liver microsomal esterases were fractionated on DEAE-cellulose after the solution of these enzymes in a solution containing 0.1 M glycyl glycine buffer, pH 7.0, and 5 × 10−4 M Lubrol W, a nonionic detergent. Elution of the enzymes from the DEAE-cellulose was accomplished by using NaCl in the glycyl glycine – Lubrol W solution.
C, CARRUTHERS, E, HEINS, A, BAUMLER
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Mechanism of reduction of nitrofurantoin on liver microsomes
Pharmacological Research Communications, 1980Summary Reduction of the nitro-group of nitrofurantoin /N-[5-Nitro-2-furfuryliden-] 1-aminohydantoin/ on liver microsomes is supported both by NADPH and NADH. The site of interaction of nitrofurantoin with microsomes appears to be on two flavoproteins, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase; interaction with the former ...
Leskovac, Vladimir, Popović, Mira
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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The esterification of dolichol by rat liver microsomes
Biochemistry, 1976The incubation of 1-[3H)dolichols with cell-free preparations from various rat tissues resulted in the formation of a labeled material which possessed the characteristics of synthetic dolichol palmitate. Rat liver microsomes were found to be a good source of the acyltransferase activity, and the properties of the reaction were investigated using ...
R W, Keenan, M E, Kruczek
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Xenobiotica; the fate of foreign compounds in biological systems, 2019
Laura Hedges +6 more
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Laura Hedges +6 more
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Oxidation of cycloalkenes in liver microsomes
Biochemical Pharmacology, 1971K C, Liebman, E, Ortiz
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