Results 241 to 250 of about 2,738,308 (324)

Chromate metabolism in liver microsomes

Biological Trace Element Research, 1979
The carcinogenicity and mutagenicity of various chromium compounds have been found to be markedly dependent on the oxidation state of the metal. The carcinogen chromate was reduced to chromium(III) by rat liver microsomes in vitro. Metabolism of chromate by microsomal enzymes occurred only in the presence of either NADPH or NADH as cofactor.
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Hydroperoxide peroxidase activity in liver microsomes

Life Sciences, 1974
Abstract The oxidation of either NADH or NADPH by cumene hydroperoxide in rat liver microsomes is described. The Km′ for the hydroperoxide varied with the pyridine nucleotide utilized (NADPH, Km′ = 0.91 mM; NADH, Km′ = 3.3 mM). Carbon monoxide did not inhibit the peroxidase activity although a variety of other agents which interact with cytochrome ...
W R, Bidlack, P, Hochstein
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Stimulation of galactosyltransferase in liver microsomes by lysolecithin

Biochemical and Biophysical Research Communications, 1974
Abstract Lysolecithin markedly stimulated membrane-bound UDP-galactose:glycoprotein galactosyltransferase. The parent molecule lecithin, phosphatidylethanolamine, lysophosphatidylethanolamine, phosphatidic acid, lysophosphatidic acid or glycerophosphorylcholine did not activate the enzyme suggesting that both fatty acyl- and phosphorylcholine groups ...
S, Mookerjea, J W, Yung
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A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

Journal of Pharmacology and Experimental Therapeutics, 1997
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine to cotinine and the relative roles of the polymorphic enzymes CYP2A6 and CYP2D6 in this metabolism were investigated.
E. Messina, R. Tyndale, E. Sellers
semanticscholar   +1 more source

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Journal of Pharmacology and Experimental Therapeutics, 1996
The HIV-1 protease inhibitor ritonavir (ABT-538) undergoes cytochrome P450-mediated biotransformation in human liver microsomes to three major metabolites, Ml, M2 and M11, with wide interindividual variation in the rates of metabolite formation.
Gondi N. Kumar, A. Rodrigues, A. Buko, J. Denissen   +3 more
semanticscholar   +1 more source

A microsomal endoribonuclease from rat liver

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
An endoribonuclease has been purified about 320-fold from the microsomes of rat liver. The enzyme had an apparent molecular weight of 54 000-58 000 and produced oligonucleotides, each consisting of 3-7 nucleotides from poly(A) and poly(U). No mononucleotide was obtained by the enzymatic hydrolysis of poly(A) and poly(U) under standard coditions.
H, Kumagai, K, Igarashi, T, Takayama, K, Watanabe, K, Sugimoto, S, Hirose   +5 more
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Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Drug Metabolism And Disposition, 1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P-450IIIA. We therefore anticipated that any drug that is an inducer or an inhibitor of this cytochrome should lead to ...
L. Pichard, I. Fabre, G. Fabre, J. Domergue, B. S. Aubert, G. Mourad, P. Maurel   +6 more
semanticscholar   +1 more source

Metabolism of pinazepam by rat liver microsomes

European Journal of Drug Metabolism and Pharmacokinetics, 1981
The pathways by which pinazepam and diazepam are metabolized by rat microsomes in vitro were studied in detail. Using a gas chromatographic technique to measure either the two parent compounds or their metabolites, it was demonstrated that pinazepam and diazepam were metabolized through the same pathways, but at different rates.
F, Marcucci, L, Airoldi, G, Zavattini, E, Mussini   +3 more
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Pigments of rat liver microsomes

Archives of Biochemistry and Biophysics, 1958
Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being due to bound hemoglobin. The content of flavine is 4 5 that of cytochrome b5. The flavine probably does not contribute to the DPNH reduced difference spectrum.
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Ethylene Formation in Rat Liver Microsomes

Science, 1966
Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
M, Lieberman, P, Hochstein
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