Results 231 to 240 of about 2,738,308 (324)

Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes

Biochemical Pharmacology, 1981
Abstract The carcinogen nitrosoacetoxymethylmethylamine (NAMM)‡ was incubated with mouse liver microsomes. The decomposition rate of NAMM and the formation of methanol were determined. After addition of an NADPH-regenerating system, formaldehyde formation resulting from metabolic degradation of the methyl group of NAMM was measured.
K E, Appel, N, Frank, M, Wiessler
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Interaction of Cimetidine with Liver Microsomes

Xenobiotica, 1979
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, V, Sunjić, R, Toso, F, Kajfez, H H, Ruf   +4 more
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Interaction of ranitidine with liver microsomes

Xenobiotica, 1982
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, T, Alebić-Kolbah, F, Kajfez, H H, Ruf   +3 more
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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Drug Metabolism And Disposition, 1995
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s in the metabolism process.
D. J. Newton, R.-W. Wang, Anthony Y. H. Lu   +2 more
semanticscholar   +1 more source

The glucuronidation of morphine by dog liver microsomes: identification of morphine-6-O-glucuronide.

Drug Metabolism And Disposition, 2000
Canines are used extensively in the pharmaceutical industry for the preclinical screening of novel therapeutics, yet comparatively little is known about the phase 2 metabolism in this species.
C. King, B. Finley, R. Franklin
semanticscholar   +1 more source

Permeability of Liver Microsomal Membranes to Glucose

Biochemical and Biophysical Research Communications, 1996
The permeability of rat liver microsomes to glucose has been studied by using (14)C-labelled D-glucose and a light-scattering technique. 1) The microsomal intravesicular apparent isotope space for D-glucose (1mM; after 5 min incubation at 22 degrees C) was 2.34 microl/mg protein, i.e., approximately 72% of the apparent water space.
MARCOLONGO, P., FULCERI, R., GIUNTI, R., BURCHELL, A., BENEDETTI, A.   +4 more
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Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

Journal of Pharmacology and Experimental Therapeutics, 1996
Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism process. In this study, cytochrome P450 isoform-dependent reactions were investigated on our human liver microsomes bank (n ...
M. Bourrié, V. Meunier, Y. Berger, G. Fabre   +3 more
semanticscholar   +1 more source

Activation of Thionophosphates by Liver Microsomes

Nature, 1959
MANY organophosphorus insecticides are poor inhibitors of cholinesterase, but are converted to potent inhibitors (‘activated’) by certain mammalian and insect tissues. The activation by liver slices was first shown by Gardiner and Kilby1 for schradan (a phosphoroamidate), and by Diggle and Gage2 for parathion (a phosphorothionate). Davison3 showed that
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Lipid peroxidation of rat liver microsomes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
1. The NADPH-dependent lipid peroxidation process was studied with microsomes and also the effects of addition of superoxide dismutase, catalase and thiourea. Only catalase and thiourea were able to inhibit lipid peroxidation. It seems that the initiating radical is the OH. radical formed by the Fenton reaction. 2.
J F, Koster, R G, Slee
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In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

Drug Metabolism And Disposition, 2000
The UDP-glucuronosyltransferases (UGTs) are a superfamily of membrane-bound enzymes whose active site is localized inside the endoplasmic reticulum.
M. Fisher, K. Campanale, B. Ackermann, M. Vandenbranden, S. Wrighton   +4 more
semanticscholar   +1 more source