Results 211 to 220 of about 2,738,308 (324)

Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Insights from k_cat measurements in matched liver and intestinal samples. [PDF]

Drug Metab Dispos
Al-Majdoub ZM, Barber J, Rostami-Hodjegan A, Galetin A, Scotcher D.   +4 more
europepmc   +1 more source

Downregulation of hepatic CYP3A isoforms by bardoxolone methyl in rats and its impact on in vivo metabolic capacity reflecting pharmacokinetics. [PDF]

Sci Rep
Hori Y, Fukuno S, Shirane H, Watanabe R, Murata K, Takenaka M, Konishi H, Nagai K.   +7 more
europepmc   +1 more source

Toxicokinetic-Oriented Assessment of Nepetalactone Using In Silico ADMET Modeling, In Vitro Rat and Human Liver Microsomes, and UHPLC-MS/MS Metabolite Characterization. [PDF]

Toxics
Stoica NB, Cascajosa-Lira A, Morea A, Catunescu GM, Hornedo-Ortega R, Guzmán-Guillén R.   +5 more
europepmc   +1 more source

Discovery of a CI-994 derivative as a dual modulator of class I histone deacetylases and Wnt/β-catenin signaling for Alzheimer's disease therapy. [PDF]

Neurotherapeutics
Lu W, Caulfield TR, Lee E, Jeevaratnam S, Wang N, Bu G, Kanekiyo T, Li Y.   +7 more
europepmc   +1 more source

Dietary allicin supplementation inhibits hepatic CYP3A37 in chickens: Evidence from in vitro and in vivo models. [PDF]

Poult Sci
Li Y, Yuan H, Wang J, Yin S, Qiu X, Yang H.   +5 more
europepmc   +1 more source

Adenosine 5'-Carboxamide-Based Inhibitors of METTL1. [PDF]

ACS Med Chem Lett
Bobileva O, Nai F, Niedrite S, Mayordomo Soler L, Leite I, Caflisch A.   +5 more
europepmc   +1 more source

Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study. [PDF]

ACS Chem Neurosci
Toriola MA, Kowalczyk ET, Medubi KM, Meyer MJ, Fernando MRT, Scholze P, Premananda N, Harrington SG, Barkley BR, Webb DA, Arnold LA.   +10 more
europepmc   +1 more source

Interaction of Cytochrome P450 3A4 with Fatty Acid Binding Protein 1 and Relevance to Drug Metabolism. [PDF]

J Med Chem
McCarty KD, Proffett DLD, Guengerich FP.
europepmc   +1 more source

Integrated genomic, transcriptomic, and microsomal metabolic profiling of cytochrome P450s in squirrels. [PDF]

J Vet Med Sci
Goto M, Watanabe K, Yohannes YB, Hasegawa N, Morita A, Banda N, Kakisaka K, Ito M, Ikenaka Y, Nakayama SM, Ishizuka M.   +10 more
europepmc   +1 more source

Effects of Newer Veterinary Macrolide Antimicrobials on the CYP3A-Dependent Metabolism in Cattle Liver Microsomes: Potential Metabolic Drug-Drug Interaction with Monensin. [PDF]

Animals (Basel)
Ichinose P, Munafó JP, Miró MV, Valente M, Moreno-Torrejón L, Larsen K, Lanusse C, Lifschitz A, Virkel G.   +8 more
europepmc   +1 more source