Results 201 to 210 of about 2,738,308 (324)

The Role of Cytochrome P450 Holoenzyme Metabolism in the Origin of Neuropathologies. [PDF]

Int J Mol Sci
Štambuk S.
europepmc   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, Volume 604, Issue 17, Page 7246-7263, 1 September 2026.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source

The Effect of Artemisinin on the Pharmacokinetics of Cyclophosphamide and Its Metabolite in Mice and Its Potential Mechanisms. [PDF]

Biomed Chromatogr
Wang H, Zhang W, Hu H, Wang S, Xie Y.
europepmc   +1 more source

An Ultra-Fast UPLC-MS/MS Method for Quantifying Ivosidenib: Application to Assessment of Metabolic Stability in Human Liver Microsomes. [PDF]

Arch Pharm (Weinheim)
Attwa MW, Abdelhameed AS, AlRabiah H, Kadi AA.   +3 more
europepmc   +1 more source

<i>In Vitro</i> characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status. [PDF]

Front Pharmacol
Akkireddy R, Yang IH, Lenkalapelly S, Kshirsagar GJ, May HA, Kang MH.   +5 more
europepmc   +1 more source

Investigating the Impact of Calcium Channel Blockers on the Pharmacokinetics of Lapatinib: Possible Role of Cytochrome P450 Enzymes and P-glycoprotein Efflux Transporters. [PDF]

Eur J Drug Metab Pharmacokinet
Desai MP, Patil PH, Rajpurohit AUS, Anand VSK, Channabasavaiah JP.   +4 more
europepmc   +1 more source

Oxidation of Uroporphyrinogens During Heme Synthesis: Role of Iron, Susceptibility and Consequences. [PDF]

Biomolecules
Smith AG.
europepmc   +1 more source

Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles. [PDF]

Chem Sci
Boschi E, Mazunin D, Mueller A, Zimmerli D, Wechsler D, Ebert MO, Bartelmus C, Binder M, Wagner B, Weinmann C, Kroll C, Haap W, Bode JW.   +12 more
europepmc   +1 more source

First-in-Human Dose Selection, Pharmacokinetics Prediction, and Clinical Validation of SYHA1805, a Novel FXR Agonist, Using Allometric Scaling and PBPK Modeling. [PDF]

Pharmaceutics
Zhang L, Zhang M, Zhou E, Zhang X, Qi H, Yao X, Liu D.   +6 more
europepmc   +1 more source

IV-EVE: EVE for Injection-ADME, Pharmacokinetic and Toxicological Evaluation for Novel Deciparticle EVE Formulation. [PDF]

Biomedicines
Chang WH, Chang N, Min SH, Lopp JM, Hoff R, Hoque T, Trieu V, Lee C.   +7 more
europepmc   +1 more source