Results 191 to 200 of about 2,738,308 (324)

5'-Nucleotidase of Rat Liver Microsomes

Journal of Biological Chemistry, 1960
H L, SEGAL, B M, BRENNER
openaire   +2 more sources

A Practical Alternative to Refine the Estimate of fmCYP3A4 and Evaluate Drug–Drug Interaction Potential for Ziftomenib Using PBPK Modeling to Inform Labeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Accurate physiologically based pharmacokinetic (PBPK) simulation of drug–drug interaction (DDI) potential requires estimation of the relative contribution of the impacted pathway. While fraction metabolized by CYP enzymes is usually estimated using dedicated clinical DDI studies with strong CYP inhibitors, this approach might not be available ...
Ian E. Templeton, Chara Litou, Hannah M. Jones, Julie Mackey Ahsan, Marilyn Tabachri, Mollie Leoni, Amitava Mitra   +6 more
wiley   +1 more source

Crocetin Halts Tumorigenesis in Metastatic Breast Cancer via Disrupting CYP2J2/EET Axis. [PDF]

ACS Omega
Manhas D, Jamwal A, Kaur G, Akhter MQ, Arora N, Kumar V, Ojha PK, Sawant SD, Bag S, Goswami A, Nandi U.   +10 more
europepmc   +1 more source

Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age‐Related Cognitive Inflexibility in Mice

Aging Cell, Volume 25, Issue 9, September 2026.
Aged mice showed substantial individual variability in cognitive inflexibility, associated with greater abundance of synapse‐associated mitochondrial proteins in the medial prefrontal cortex. The mitochondria‐targeted antioxidant MitoQ improved attentional set‐shifting performance and reduced the abundance of synaptosomal mitochondrial proteins ...
Rui Yamada, Hirotaka Nagai, Chisato Numa, Yunhui Zhu, Midori Nagai, Kohei Ota, Yusuke Kawashima, Nobuhiko Ohno, Tomoyuki Furuyashiki   +8 more
wiley   +1 more source

Characterization of Atrasentan Metabolic Pathway in Human Liver Microsomes Using Feature-Based Molecular Networking. [PDF]

Pharmaceutics
Seo HJ, Liang Z, Kim EH, Liu KH.
europepmc   +1 more source

Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
We narrated the identification of benzotriazole‐based cereblon ligands for their potential use either in PROTAC or CELMoD chemical space, through systematic design and SAR studies, synthesis, biological, and docking experiments resulting in a non‐cytotoxic, potent, drug‐like compound 13, offering scope for optimization to yield an in vivo efficacious ...
Pramit Ganguly, Mrinalkanti Kundu, Tonmoy Sarkar, Gillian Dcosta, Kankana Banerjee, Ritama Banerjee, Arun K. Hajra, Sk Sahabuddin, Sohini Basu, Avratanu Das, Suparna Das, Rajib Barik, Md Ashif Ali   +12 more
wiley   +1 more source

Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications. [PDF]

Sci Rep
Lee MS, Song IS, Jang Y, Cho YY, Lee JY, Kang HC, Kim JH, Lee HS.   +7 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Predict Human Starting Dose and Pharmacokinetics for Rocbrutinib

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Rocbrutinib is a fourth‐generation Bruton's tyrosine kinase (BTK) inhibitor that covalently binds wild‐type BTK and non‐covalently engages the C481S mutant. Its pharmacokinetic (PK) characteristics in healthy Chinese subjects remain unclear. This study aimed to support maximum recommended starting dose (MRSD) selection and predict exposure of ...
Lu Wang, Dandan Yang, Rong Shao, Jinliang Chen, Xiaodan Wang, Zheng Wang, Bo Jiang   +6 more
wiley   +1 more source

Fangchinoline (2021-2026): A Multitarget Bisbenzylisoquinoline Alkaloid With Emerging Anti-Infective Potential. [PDF]

J Trop Med
Sirwi A, Mohamed HM, Mohamed GA, Eid BG, Abdallah HM, Ibrahim SRM.   +5 more
europepmc   +1 more source

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago – Sinorhizobium symbiosis

New Phytologist, Volume 251, Issue 5, Page 2867-2887, September 2026.
MtSymCRK–MtGRF8‐14‐3‐3a, e, h and i functional model in R‐108 nodules. Summary In Medicago littoralis R‐108, Symbiotic CYSTEINE‐RICH RECEPTOR‐LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection.
Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S. Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber   +9 more
wiley   +1 more source