Results 191 to 200 of about 34,918 (236)

Metabolism of Dietary Flavonoids in Liver Microsomes

Current Drug Metabolism, 2013
Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4'-, C-3', C-6 and C-8- position when there is a single or no hydroxy group ...
Jianbo, Xiao, Petra, Högger
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FRACTIONATION OF MOUSE LIVER MICROSOMAL ESTERASES

Canadian Journal of Biochemistry, 1965
Mouse liver microsomal esterases were fractionated on DEAE-cellulose after the solution of these enzymes in a solution containing 0.1 M glycyl glycine buffer, pH 7.0, and 5 × 10−4 M Lubrol W, a nonionic detergent. Elution of the enzymes from the DEAE-cellulose was accomplished by using NaCl in the glycyl glycine – Lubrol W solution.
C, CARRUTHERS, E, HEINS, A, BAUMLER
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Mechanism of reduction of nitrofurantoin on liver microsomes

Pharmacological Research Communications, 1980
Summary Reduction of the nitro-group of nitrofurantoin /N-[5-Nitro-2-furfuryliden-] 1-aminohydantoin/ on liver microsomes is supported both by NADPH and NADH. The site of interaction of nitrofurantoin with microsomes appears to be on two flavoproteins, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase; interaction with the former ...
Leskovac, Vladimir, Popović, Mira
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The lipid composition of human liver microsomes

Lipids, 1982
AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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THE MECHANISM OF SCHRADAN ACTIVATION BY LIVER MICROSOMES

Canadian Journal of Biochemistry and Physiology, 1957
The mechanism by which schradan is converted to a powerful anticholinesterase by fortified liver homogenates has been studied. A scheme is proposed involving the production from DPNH of hydrogen peroxide, which then oxidizes an unknown microsomal factor with the aid of catalase. The factor in turn oxidizes schradan.
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Mannosyltransfer reactions in rabbit liver microsomes

Biochemical and Biophysical Research Communications, 1976
Abstract Rabbit liver microsomes catalyzed mannosyltransfer from GDP-[14C]mannose to free D -mannose resulting in the synthesis of α-1,2-, α-1,3-, and α-1,6-mannosyl-mannose. Whereas formation of α-1,2-mannosyl-mannose was stimulated by the addition of manganese chloride or nickel chloride and was inhibited by EDTA, synthesis of α-1,3-mannosyl ...
J S, Schutzbach, A K, Verma
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Interaction of piperine with rat liver microsomes

Toxicology, 1987
Pretreatment of adult male albino rats with piperine did not induce cytochrome P-450 whereas safrole did cause such induction. Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns.
B G, Bhat, N, Chandrasekhara
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Kavalactone Metabolism in Rat Liver Microsomes

Phytotherapy Research, 2011
The specific CYP enzymes involved in kavalactone (KLT) metabolism and their kinetics have not been fully examined. This study used rat liver microsomes (RLM) to determine kavain (KA), methysticin (MTS) and desmethoxyyangonin (DMY) enzyme kinetic parameters, to elucidate the major CYP450 isoforms involved in KLT metabolism and to examine gender ...
Shuang, Fu, Anthony, Rowe, Iqbal, Ramzan
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Metabolism of diazinon by fish liver microsomes

Bulletin of Environmental Contamination and Toxicology, 1972
The results of these experiments indicate that thein vitro metabolism of diazinon is accomplished by enzyme preparations from fish liver homogenates, with the microsomal fraction being most active. The enzyme system responsible for diazinon metabolism in channel catfish liver microsomes required NADPH and oxygen for the oxidative desulfuration of ...
J W, Hogan, C O, Knowles
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Lipid peroxidation of rat liver microsomes

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
1. The NADPH-dependent lipid peroxidation process was studied with microsomes and also the effects of addition of superoxide dismutase, catalase and thiourea. Only catalase and thiourea were able to inhibit lipid peroxidation. It seems that the initiating radical is the OH. radical formed by the Fenton reaction. 2.
J F, Koster, R G, Slee
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